A Diels-Alder polymer platform for thermally enhanced drug release toward efficient local cancer chemotherapy.
30 Bio-inspired and biomedical materials; 211 Scaffold/Tissue engineering/Drug delivery
Diels-alder reaction
alternating magnetic field
cancer
chemotherapy
gemcitabine
local drug delivery
Journal
Science and technology of advanced materials
ISSN: 1468-6996
Titre abrégé: Sci Technol Adv Mater
Pays: United States
ID NLM: 101614420
Informations de publication
Date de publication:
24 Jun 2021
24 Jun 2021
Historique:
entrez:
5
7
2021
pubmed:
6
7
2021
medline:
6
7
2021
Statut:
epublish
Résumé
We reports a novel thermally enhanced drug release system synthesized via a dynamic Diels-Alder (DA) reaction to develop chemotherapy for pancreatic cancer. The anticancer prodrug was designed by tethering gemcitabine (GEM) to poly(furfuryl methacrylate) (PFMA) via
Identifiants
pubmed: 34220340
doi: 10.1080/14686996.2021.1939152
pii: 1939152
pmc: PMC8231351
doi:
Types de publication
Journal Article
Langues
eng
Pagination
522-531Informations de copyright
© 2021 The Author(s). Published by National Institute for Materials Science in partnership with Taylor & Francis Group.
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