The Function of the Hypothalamic-Pituitary-Adrenal Axis During Experimental Autoimmune Encephalomyelitis: Involvement of Oxidative Stress Mediators.
cytokines
experimental autoimmune encephalomyelitis
hypothalamic–pituitary–adrenal axis
multiple sclerosis
oxidative stress
Journal
Frontiers in neuroscience
ISSN: 1662-4548
Titre abrégé: Front Neurosci
Pays: Switzerland
ID NLM: 101478481
Informations de publication
Date de publication:
2021
2021
Historique:
received:
04
01
2021
accepted:
29
04
2021
entrez:
5
7
2021
pubmed:
6
7
2021
medline:
6
7
2021
Statut:
epublish
Résumé
Multiple sclerosis (MS) is an inflammatory, demyelinating disease with an unknown origin. Previous studies showed the involvement of the hypothalamic-pituitary-adrenal (HPA) axis to susceptibility to autoimmune diseases, including MS, and its best-characterized animal model, experimental autoimmune encephalomyelitis (EAE). During MS/EAE, innate immune cells are activated and release cytokines and other inflammatory mediators, leading to a vicious cycle of inflammation. In response to inflammation, the activated HPA axis modulates immune responses
Identifiants
pubmed: 34220419
doi: 10.3389/fnins.2021.649485
pmc: PMC8248369
doi:
Types de publication
Journal Article
Langues
eng
Pagination
649485Informations de copyright
Copyright © 2021 Trifunovic, Stevanovic, Milosevic, Ristic, Janjic, Bjelobaba, Savic, Bozic, Jakovljevic, Tesovic, Laketa and Lavrnja.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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