A Retrospective Case Series Analysis of the Relationship Between Phenylalanine: Tyrosine Ratio and Cerebral Glucose Metabolism in Classical Phenylketonuria and Hyperphenylalaninemia.
[18F]fluorodeoxyglucose PET
hyperphenylalaninemia
intellectual function
phenylalanine:tyrosine ratio
phenylketonuria
Journal
Frontiers in neuroscience
ISSN: 1662-4548
Titre abrégé: Front Neurosci
Pays: Switzerland
ID NLM: 101478481
Informations de publication
Date de publication:
2021
2021
Historique:
received:
05
02
2021
accepted:
28
04
2021
entrez:
5
7
2021
pubmed:
6
7
2021
medline:
6
7
2021
Statut:
epublish
Résumé
We retrospectively examined the relationship between blood biomarkers, in particular the historical mean phenylalanine to tyrosine (Phe:Tyr) ratio, and cerebral glucose metabolism. We hypothesized that the historical mean Phe:Tyr ratio would be more predictive of cerebral glucose metabolism than the phenylalanine (Phe) level alone. We performed a retrospective case series analysis involving 11 adult classical phenylketonuria/hyperphenylalaninemia patients under the care of an Inherited Metabolic & Neuropsychiatry Clinic who had complained of memory problems, collating casenote data from blood biochemistry, and clinical [
Identifiants
pubmed: 34220424
doi: 10.3389/fnins.2021.664525
pmc: PMC8248344
doi:
Types de publication
Journal Article
Langues
eng
Pagination
664525Subventions
Organisme : Medical Research Council
ID : MR/N013042/1
Pays : United Kingdom
Informations de copyright
Copyright © 2021 McGinnity, Riaño Barros, Guedj, Girard, Symeon, Walker, Barrington, Summers, Pitkanen and Rahman.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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