Phosphorylation and

Alzheimer’s disease NMR spectroscopy O-GlcNAc glycosylation microtubule-associated protein tau phosphorylation protein aggregation

Journal

Frontiers in molecular neuroscience
ISSN: 1662-5099
Titre abrégé: Front Mol Neurosci
Pays: Switzerland
ID NLM: 101477914

Informations de publication

Date de publication:
2021
Historique:
received: 30 01 2021
accepted: 21 05 2021
entrez: 5 7 2021
pubmed: 6 7 2021
medline: 6 7 2021
Statut: epublish

Résumé

Phosphorylation of the neuronal microtubule-associated Tau protein plays a critical role in the aggregation process leading to the formation of insoluble intraneuronal fibrils within Alzheimer's disease (AD) brains. In recent years, other posttranslational modifications (PTMs) have been highlighted in the regulation of Tau (dys)functions. Among these PTMs, the

Identifiants

pubmed: 34220449
doi: 10.3389/fnmol.2021.661368
pmc: PMC8249575
doi:

Types de publication

Journal Article

Langues

eng

Pagination

661368

Informations de copyright

Copyright © 2021 Cantrelle, Loyens, Trivelli, Reimann, Despres, Gandhi, Hackenberger, Landrieu and Smet-Nocca.

Déclaration de conflit d'intérêts

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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Auteurs

François-Xavier Cantrelle (FX)

Risk Factors and Molecular Determinants of Aging-Related Diseases, U1167, Institut Pasteur de Lille, CHU Lille, INSERM, University of Lille, Lille, France.
CNRS, ERL9002 - Integrative Structural Biology, Lille, France.

Anne Loyens (A)

Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer, U1172, CHU Lille, INSERM, University of Lille, Lille, France.

Xavier Trivelli (X)

Université de Lille, CNRS, INRAE, Centrale Lille, Université d'Artois, Lille, France.

Oliver Reimann (O)

Leibniz-Forschungsinstitut für Molekulare Pharmakologie, Berlin, Germany.
Institut für Chemie, Humboldt-Universität zu Berlin, Berlin, Germany.

Clément Despres (C)

Risk Factors and Molecular Determinants of Aging-Related Diseases, U1167, Institut Pasteur de Lille, CHU Lille, INSERM, University of Lille, Lille, France.

Neha S Gandhi (NS)

Centre for Genomics and Personalised Health, Cancer and Ageing Research Program, School of Chemistry and Physics, Faculty of Science and Engineering, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, QLD, Australia.

Christian P R Hackenberger (CPR)

Leibniz-Forschungsinstitut für Molekulare Pharmakologie, Berlin, Germany.
Institut für Chemie, Humboldt-Universität zu Berlin, Berlin, Germany.

Isabelle Landrieu (I)

Risk Factors and Molecular Determinants of Aging-Related Diseases, U1167, Institut Pasteur de Lille, CHU Lille, INSERM, University of Lille, Lille, France.
CNRS, ERL9002 - Integrative Structural Biology, Lille, France.

Caroline Smet-Nocca (C)

Risk Factors and Molecular Determinants of Aging-Related Diseases, U1167, Institut Pasteur de Lille, CHU Lille, INSERM, University of Lille, Lille, France.
CNRS, ERL9002 - Integrative Structural Biology, Lille, France.

Classifications MeSH