A Short-Term Intervention of High-Intensity Exercise and Anodal-tDCS on Motor Learning in Middle-Aged Adults: An RCT.
aerobic exercise
cognition
motor cortex
non-invasive brain stimulation
transcranial direct current stimulation
Journal
Frontiers in human neuroscience
ISSN: 1662-5161
Titre abrégé: Front Hum Neurosci
Pays: Switzerland
ID NLM: 101477954
Informations de publication
Date de publication:
2021
2021
Historique:
received:
17
02
2021
accepted:
21
05
2021
entrez:
5
7
2021
pubmed:
6
7
2021
medline:
6
7
2021
Statut:
epublish
Résumé
High-intensity exercise has enhanced motor learning in healthy young adults. Anodal-transcranial direct current stimulation (a-tDCS) may optimize these effects. This study aimed to determine the effects of a short-term high-intensity interval exercise intervention either with or without a-tDCS on the learning and retention of a novel motor task in middle-aged adults. Forty-two healthy middle-aged adults (age = 44.6 ± 6.3, female = 76%) were randomized into three groups: exercise and active a-tDCS, exercise and sham a-tDCS, and a non-exercise and sham a-tDCS control. Participants completed a baseline testing session, followed by three intervention sessions 48-h apart. The exercise groups completed 20-min of high-intensity exercise followed by a novel sequential visual isometric pinch task (SVIPT) while receiving 20-min of 1.5 mA a-tDCS, or sham tDCS. The control group completed 20-min of reading before receiving sham a-tDCS during the SVIPT. Learning was assessed by skill change within and between intervention sessions. Participants returned 5-7 days after the final intervention session and performed the SVIPT task to assess retention. All three groups showed evidence of learning on the SVIPT task. Neither group displayed enhanced overall learning or retention when compared to the control group. High-intensity exercise with or without a-tDCS did not improve learning or retention of a novel motor task in middle-aged adults. The methodological framework provides direction for future research to investigate the potential of differing exercise intensity effects on learning and retention.
Identifiants
pubmed: 34220470
doi: 10.3389/fnhum.2021.661079
pmc: PMC8241928
doi:
Types de publication
Journal Article
Langues
eng
Pagination
661079Informations de copyright
Copyright © 2021 Quinlan, Rattray, Pryor, Northey, Coxon, Cherbuin and Andrews.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
Exp Brain Res. 2019 Sep;237(9):2331-2344
pubmed: 31289887
Geriatr Gerontol Int. 2013 Jan;13(1):19-27
pubmed: 22817645
Cortex. 2005 Aug;41(4):560-9
pubmed: 16042032
PLoS One. 2015 Oct 27;10(10):e0141393
pubmed: 26506413
Trends Neurosci. 2006 Jan;29(1):58-64
pubmed: 16290273
J Int Neuropsychol Soc. 2015 Nov;21(10):791-801
pubmed: 26581791
Front Cell Neurosci. 2015 May 12;9:181
pubmed: 26029052
Brain Res. 2010 Jun 23;1341:12-24
pubmed: 20381468
J Physiol. 2003 Nov 15;553(Pt 1):293-301
pubmed: 12949224
Front Syst Neurosci. 2014 Jan 24;8:2
pubmed: 24478640
J Am Coll Cardiol. 2001 Jan;37(1):153-6
pubmed: 11153730
J Neurosci. 2014 Jan 15;34(3):1037-50
pubmed: 24431461
Trends Cogn Sci. 2015 Jan;19(1):13-20
pubmed: 25467129
J Affect Disord. 2000 Jan-Mar;57(1-3):83-93
pubmed: 10708819
Neurobiol Aging. 2016 Apr;40:127-137
pubmed: 26973112
Neuropsychologia. 2011 Apr;49(5):800-804
pubmed: 21335013
J Appl Physiol (1985). 2014 Dec 1;117(11):1325-36
pubmed: 25257866
Cereb Cortex. 2020 Jan 10;30(1):101-112
pubmed: 31041988
Brain Stimul. 2017 Jan - Feb;10(1):51-58
pubmed: 28104085
Proc Natl Acad Sci U S A. 2003 Oct 14;100(21):12492-7
pubmed: 14530407
Brain Stimul. 2014 May-Jun;7(3):468-75
pubmed: 24630848
J Appl Physiol (1985). 2015 Dec 15;119(12):1363-73
pubmed: 26472862
Basic Clin Neurosci. 2015 Oct;6(4):231-8
pubmed: 26649161
Medicina (Kaunas). 2019 Sep 05;55(9):
pubmed: 31491932
Eur J Prev Cardiol. 2012 Aug;19(4):670-86
pubmed: 22637742
J Neurosci. 1999 Jun 15;19(12):4972-83
pubmed: 10366630
J Vis Exp. 2011 May 23;(51):
pubmed: 21654618
Proc Natl Acad Sci U S A. 2009 Feb 3;106(5):1590-5
pubmed: 19164589
Clin Neurophysiol. 2017 Sep;128(9):1774-1809
pubmed: 28709880
Clin Neurophysiol. 2004 May;115(5):1063-8
pubmed: 15066531
J Cogn Neurosci. 2017 Apr;29(4):593-604
pubmed: 27897671
Sports Med. 2013 May;43(5):313-38
pubmed: 23539308
Front Mol Neurosci. 2010 Feb 09;3:1
pubmed: 20162032
Neural Plast. 2018 Dec 23;2018:4756785
pubmed: 30675151
Neuron. 2010 Apr 29;66(2):198-204
pubmed: 20434997
Front Psychol. 2018 Apr 27;9:509
pubmed: 29755380
Neurosci Biobehav Rev. 2020 Sep;116:365-381
pubmed: 32565171
J Clin Exp Neuropsychol. 2007 Nov;29(8):842-53
pubmed: 17852593
Neurobiol Learn Mem. 2014 Dec;116:46-58
pubmed: 25128877
PLoS One. 2012;7(9):e44594
pubmed: 22973462
J Sci Med Sport. 2020 Apr;23(4):408-414
pubmed: 31759829
Sci Rep. 2017 Jul 19;7(1):5808
pubmed: 28724914
Front Aging Neurosci. 2017 May 23;9:147
pubmed: 28588474
Front Psychiatry. 2017 Aug 14;8:147
pubmed: 28855877
Front Hum Neurosci. 2019 Jan 11;12:534
pubmed: 30687048
Am J Phys Med Rehabil. 2018 Oct;97(10):727-733
pubmed: 29683810
Eur J Neurosci. 2019 Oct;50(8):3261-3268
pubmed: 30888090
BMJ. 1988 Oct 8;297(6653):897-9
pubmed: 3140969
Neurosci Biobehav Rev. 2010 Apr;34(5):721-33
pubmed: 19850077
Nat Rev Neurosci. 2004 Jul;5(7):576-82
pubmed: 15208699
J Sports Sci Med. 2013 Sep 01;12(3):502-11
pubmed: 24149158
PLoS One. 2013 May 14;8(5):e63885
pubmed: 23691107
Cortex. 2019 Jun;115:324-334
pubmed: 30903834
Proc Natl Acad Sci U S A. 2014 Aug 19;111(33):12228-33
pubmed: 25071212
Psychol Bull. 1961 Jul;58:257-73
pubmed: 13681395
Neuroscience. 2020 Sep 1;443:71-83
pubmed: 32682826
J Cogn Neurosci. 2003 May 15;15(4):619-26
pubmed: 12803972
Brain Stimul. 2019 Jul - Aug;12(4):1086-1088
pubmed: 31010792
PLoS One. 2016 Jul 25;11(7):e0159589
pubmed: 27454423