Maturation of Heterogeneity in Afferent Synapse Ultrastructure in the Mouse Cochlea.
FIB-SEM
developmental maturation
modiolar
pillar
postsynaptic density
presynaptic density
ribbon synapse ultrastructure
synaptic vesicles
Journal
Frontiers in synaptic neuroscience
ISSN: 1663-3563
Titre abrégé: Front Synaptic Neurosci
Pays: Switzerland
ID NLM: 101548972
Informations de publication
Date de publication:
2021
2021
Historique:
received:
09
03
2021
accepted:
11
05
2021
entrez:
5
7
2021
pubmed:
6
7
2021
medline:
6
7
2021
Statut:
epublish
Résumé
Auditory nerve fibers (ANFs) innervating the same inner hair cell (IHC) may have identical frequency tuning but different sound response properties. In cat and guinea pig, ANF response properties correlate with afferent synapse morphology and position on the IHC, suggesting a causal structure-function relationship. In mice, this relationship has not been fully characterized. Here we measured the emergence of synaptic morphological heterogeneities during maturation of the C57BL/6J mouse cochlea by comparing postnatal day 17 (p17, ∼3 days after hearing onset) with p34, when the mouse cochlea is mature. Using serial block face scanning electron microscopy and three-dimensional reconstruction we measured the size, shape, vesicle content, and position of 70 ribbon synapses from the mid-cochlea. Several features matured over late postnatal development. From p17 to p34, presynaptic densities (PDs) and post-synaptic densities (PSDs) became smaller on average (PDs: 0.75 to 0.33; PSDs: 0.58 to 0.31 μm
Identifiants
pubmed: 34220482
doi: 10.3389/fnsyn.2021.678575
pmc: PMC8248813
doi:
Types de publication
Journal Article
Langues
eng
Pagination
678575Subventions
Organisme : NIDCD NIH HHS
ID : R01 DC014712
Pays : United States
Informations de copyright
Copyright © 2021 Payne, Joens, Chung, Skigen, Frank, Gattani, Vaughn, Schwed, Nester, Bhattacharyya, Iyer, Davis, Carlquist, Patel, Fitzpatrick and Rutherford.
Déclaration de conflit d'intérêts
MJ was employed by TESCAN. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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