Use of EP3533-Enhanced Magnetic Resonance Imaging as a Measure of Disease Progression in Skeletal Muscle of

EP3533 fibrosis magnetic resonance image mdx mouse model muscular dystrophy

Journal

Frontiers in neurology
ISSN: 1664-2295
Titre abrégé: Front Neurol
Pays: Switzerland
ID NLM: 101546899

Informations de publication

Date de publication:
2021
Historique:
received: 01 12 2020
accepted: 12 05 2021
entrez: 5 7 2021
pubmed: 6 7 2021
medline: 6 7 2021
Statut: epublish

Résumé

As putative treatments are developed for Duchenne muscular dystrophy (DMD), sensitive, non-invasive measures are increasingly important to quantify disease progression. Fibrosis is one of the histological hallmarks of muscular dystrophy and has been directly linked to prognosis. EP3533 is a novel contrast agent with an affinity to collagen 1 that has demonstrated a significant and high correlation to

Identifiants

pubmed: 34220666
doi: 10.3389/fneur.2021.636719
pmc: PMC8248789
doi:

Types de publication

Journal Article

Langues

eng

Pagination

636719

Informations de copyright

Copyright © 2021 Murphy, Greally, O'Hogain, Blamire, Caravan and Straub.

Déclaration de conflit d'intérêts

PC has equity in, and is a consultant to Collagen Medical LLC which holds the patent rights to EP-3533. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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Auteurs

Alexander Peter Murphy (AP)

The Institute of Cancer and Genomics, Birmingham University, Birmingham, United Kingdom.
The John Walton Muscular Dystrophy Research Centre, Institute of Translational and Clinical Research, Newcastle University, Newcastle upon Tyne, United Kingdom.

Elizabeth Greally (E)

The John Walton Muscular Dystrophy Research Centre, Institute of Translational and Clinical Research, Newcastle University, Newcastle upon Tyne, United Kingdom.

Dara O'Hogain (D)

Newcastle Magnetic Resonance Centre, Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, United Kingdom.

Andrew Blamire (A)

Newcastle Magnetic Resonance Centre, Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, United Kingdom.

Peter Caravan (P)

Department of Radiology, Martinos Center for Biomedical Imaging, Harvard Medical School, Massachusetts General Hospital, Charlestown, MA, United States.

Volker Straub (V)

The Institute of Cancer and Genomics, Birmingham University, Birmingham, United Kingdom.
Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle University, Newcastle upon Tyne, United Kingdom.

Classifications MeSH