Tissue Damage in Radiation-Induced Oral Mucositis Is Mitigated by IL-17 Receptor Signaling.
Animals
Cell Proliferation
Cell Survival
Disease Models, Animal
Interleukin-1
/ metabolism
Interleukin-17
/ genetics
Mice, Knockout
Neutrophil Infiltration
Radiation Injuries
/ genetics
Receptors, Interleukin-1
/ metabolism
Receptors, Interleukin-17
/ genetics
Signal Transduction
Stomatitis
/ genetics
Tongue
/ immunology
Transcriptome
Wound Healing
healing
inflammation
interleukin-17
oral mucosa
oral mucositis (OM)
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2021
2021
Historique:
received:
29
03
2021
accepted:
31
05
2021
entrez:
5
7
2021
pubmed:
6
7
2021
medline:
29
10
2021
Statut:
epublish
Résumé
Oral mucositis (OM) is a treatment-limiting adverse side effect of radiation and chemotherapy. Approximately 80% of patients undergoing radiotherapy (RT) for head and neck cancers (HNC) develop OM, representing a major unmet medical condition. Our understanding of the immunopathogenesis of OM is limited, due in part to the surprising paucity of information regarding healing mechanisms in the oral mucosa. RNAseq of oral tissue in a murine model that closely mimics human OM, showed elevated expression of IL-17 and related immune pathways in response to head and neck irradiation (HNI). Strikingly, mice lacking the IL-17 receptor (IL-17RA) exhibited markedly more severe OM. Restoration of the oral mucosa was compromised in
Identifiants
pubmed: 34220843
doi: 10.3389/fimmu.2021.687627
pmc: PMC8248500
doi:
Substances chimiques
Il17ra protein, mouse
0
Interleukin-1
0
Interleukin-17
0
Receptors, Interleukin-1
0
Receptors, Interleukin-17
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
687627Subventions
Organisme : NIAID NIH HHS
ID : U19 AI110820
Pays : United States
Informations de copyright
Copyright © 2021 Saul-McBeth, Dillon, Lee, Launder, Kratch, Abutaha, Williamson, Schroering, Michalski, Biswas, Conti, Shetty, McCracken, Bruno, Parsai and Conti.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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