DNA Repair Gene Polymorphisms and Chromosomal Aberrations in Exposed Populations.
DNA repair
association study
chromosomal aberrations
exposure
polymorphism
Journal
Frontiers in genetics
ISSN: 1664-8021
Titre abrégé: Front Genet
Pays: Switzerland
ID NLM: 101560621
Informations de publication
Date de publication:
2021
2021
Historique:
received:
07
04
2021
accepted:
30
04
2021
entrez:
5
7
2021
pubmed:
6
7
2021
medline:
6
7
2021
Statut:
epublish
Résumé
DNA damage and unrepaired or insufficiently repaired DNA double-strand breaks as well as telomere shortening contribute to the formation of structural chromosomal aberrations (CAs). Non-specific CAs have been used in the monitoring of individuals exposed to potential carcinogenic chemicals and radiation. The frequency of CAs in peripheral blood lymphocytes (PBLs) has been associated with cancer risk and the association has also been found in incident cancer patients. CAs include chromosome-type aberrations (CSAs) and chromatid-type aberrations (CTAs) and their sum CAtot. In the present study, we used data from our published genome-wide association studies (GWASs) and extracted the results for 153 DNA repair genes for 607 persons who had occupational exposure to diverse harmful substances/radiation and/or personal exposure to tobacco smoking. The analyses were conducted using linear and logistic regression models to study the association of DNA repair gene polymorphisms with CAs. Considering an arbitrary cutoff level of 5 × 10
Identifiants
pubmed: 34220964
doi: 10.3389/fgene.2021.691947
pmc: PMC8242355
doi:
Types de publication
Journal Article
Langues
eng
Pagination
691947Informations de copyright
Copyright © 2021 Niazi, Thomsen, Smolkova, Vodickova, Vodenkova, Kroupa, Vymetalkova, Kazimirova, Barancokova, Volkovova, Staruchova, Hoffmann, Nöthen, Dusinska, Musak, Vodicka, Hemminki and Försti.
Déclaration de conflit d'intérêts
HT was an employee at GeneWerk GmbH, which had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript, or in the decision to publish the results. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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