Is Intra-Articular Administration of Fibrinogen Effective in Postoperative Total Knee Arthroplasty Blood Loss? A Randomized Clinical Trial.
Blood Loss
Fibrinogen
Intra-Articular Injection
Total Knee Arthroplasty
Journal
Anesthesiology and pain medicine
ISSN: 2228-7523
Titre abrégé: Anesth Pain Med
Pays: Netherlands
ID NLM: 101585412
Informations de publication
Date de publication:
Feb 2021
Feb 2021
Historique:
received:
15
08
2020
revised:
18
11
2020
accepted:
18
11
2020
entrez:
5
7
2021
pubmed:
6
7
2021
medline:
6
7
2021
Statut:
epublish
Résumé
The purpose of this study was to evaluate the effect of intra-articular injection of fibrinogen on postoperative bleeding following total knee arthroplasty. A double-blind randomized clinical trial was conducted on 40 patients aged 40 - 70 years under spinal anesthesia candidate for total knee arthroplasty in Golestan hospital, Ahwaz, Iran, in 2017-2018. Patients were divided into fibrinogen intra-articular injection (n = 20) and control (n = 20) groups. The amounts of blood loss and blood transfusion requirement were recorded. Hemoglobin (Hb), hematocrit (HCT), international normalized ratio (INR), platelet (PLT), prothrombin time (PT), and partial thromboplastin time (PTT) were recorded before and after the surgery. There was no significant difference in the average amount of intraoperative blood loss between the groups (P > 0.05). The average amount of blood loss 24 hours after the surgery was significantly lower in the fibrinogen group than in the control group (fibrinogen group 350.61 ± 120.32 cc; control group 540.00 ± 170.21 cc; P = 0.0002). There were significant differences in transfusion between the groups (fibrinogen group 250 ± 20 cc; control group 350 ± 50 cc; P < 0.0001). There was a significant difference between the two groups in 24 h postoperative Hb and HCT (P < 0.001). Intra-articular fibrinogen administration may reduce acute bleeding and can be used as an effective intervention to prevent further bleeding and the need for transfusion in patients undergoing total knee arthroplasty.
Identifiants
pubmed: 34221932
doi: 10.5812/aapm.107431
pmc: PMC8236676
doi:
Types de publication
Journal Article
Langues
eng
Pagination
e107431Informations de copyright
Copyright © 2020, Author(s).
Déclaration de conflit d'intérêts
Conflict of Interests: The authors of this manuscript have no conflict of interest.
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