Hippocampal vascularization patterns exert local and distant effects on brain structure but not vascular pathology in old age.
brain structure
cerebral small vessel disease
resilience
resistance
vascularization
Journal
Brain communications
ISSN: 2632-1297
Titre abrégé: Brain Commun
Pays: England
ID NLM: 101755125
Informations de publication
Date de publication:
Jul 2021
Jul 2021
Historique:
received:
13
02
2021
revised:
25
04
2021
accepted:
03
06
2021
entrez:
5
7
2021
pubmed:
6
7
2021
medline:
6
7
2021
Statut:
epublish
Résumé
The hippocampus within the medial temporal lobe is highly vulnerable to age-related pathology such as vascular disease. We examined hippocampal vascularization patterns by harnessing the ultra-high resolution of 7 Tesla magnetic resonance angiography. Dual-supply hemispheres with a contribution of the anterior choroidal artery to hippocampal blood supply were distinguished from single-supply ones with a sole dependence on the posterior cerebral artery. A recent study indicated that a dual vascular supply is related to preserved cognition and structural hippocampal integrity in old age and vascular disease. Here, we examined the regional specificity of these structural benefits at the level of medial temporal lobe sub-regions and hemispheres. In a cross-sectional study with an older cohort of 17 patients with cerebral small vessel disease (70.7
Identifiants
pubmed: 34222874
doi: 10.1093/braincomms/fcab127
pii: fcab127
pmc: PMC8249103
doi:
Types de publication
Journal Article
Langues
eng
Pagination
fcab127Informations de copyright
© The Author(s) (2021). Published by Oxford University Press on behalf of the Guarantors of Brain.
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