Mild intermittent hypoxia exposure induces metabolic and molecular adaptations in men with obesity.

Adaptation, Physiological Adipose Tissue / metabolism Adult Aged Humans Hypoxia / metabolism Male Middle Aged Muscle, Skeletal / metabolism Obesity / metabolism Overweight / metabolism Oxygen / metabolism
Hypoxia exposure Inflammation Insulin sensitivity Obesity RCT Substrate metabolism

Journal

Molecular metabolism
ISSN: 2212-8778
Titre abrégé: Mol Metab
Pays: Germany
ID NLM: 101605730

Informations de publication

Date de publication:
11 2021
Historique:
received: 28 04 2021
revised: 15 06 2021
accepted: 30 06 2021
pubmed: 6 7 2021
medline: 25 3 2022
entrez: 5 7 2021
Statut: ppublish

Résumé

Recent studies suggest that hypoxia exposure may improve glucose homeostasis, but well-controlled human studies are lacking. We hypothesized that mild intermittent hypoxia (MIH) exposure decreases tissue oxygen partial pressure (pO In a randomized, controlled, single-blind crossover study, 12 men who were overweight/obese were exposed to MIH (15 % O MIH decreased systemic oxygen saturation (92.0 ± 0.5 % vs 97.1 ± 0.3, p < 0.001, respectively), AT pO Our findings demonstrate for the first time that 7-day MIH reduces AT and SM pO This study is registered at the Netherlands Trial Register (NL7120/NTR7325).

Identifiants

DOI: 10.1016/j.molmet.2021.101287 PMID: 34224918 PMC: PMC8355948
pubmed: 34224918
pii: S2212-8778(21)00132-0
doi: 10.1016/j.molmet.2021.101287
pmc: PMC8355948
pii:
doi:

Substances chimiques

Oxygen S88TT14065

Banques de données

NTR
['NL7120', 'NTR7325']

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

101287

Informations de copyright

Copyright © 2021 The Author(s). Published by Elsevier GmbH.. All rights reserved.

Auteurs

Rens L J van Meijel (RLJ)

Department of Human Biology, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Center(+), Maastricht, the Netherlands.

Max A A Vogel (MAA)

Department of Human Biology, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Center(+), Maastricht, the Netherlands.

Johan W E Jocken (JWE)

Department of Human Biology, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Center(+), Maastricht, the Netherlands.

Lars M M Vliex (LMM)

Department of Human Biology, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Center(+), Maastricht, the Netherlands.

Joey S J Smeets (JSJ)

Department of Human Biology, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Center(+), Maastricht, the Netherlands.

Nicole Hoebers (N)

Department of Human Biology, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Center(+), Maastricht, the Netherlands.

Joris Hoeks (J)

Department of Nutrition and Movement Sciences, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Center(+), Maastricht, the Netherlands.

Yvonne Essers (Y)

Department of Human Biology, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Center(+), Maastricht, the Netherlands.

Paul F M Schoffelen (PFM)

Department of Human Biology, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Center(+), Maastricht, the Netherlands; Department of Nutrition and Movement Sciences, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Center(+), Maastricht, the Netherlands.

Henrike Sell (H)

Paul-Langerhans-Group for Integrative Physiology, German Diabetes Center, Dusseldorf, Germany.

Sander Kersten (S)

Nutrition, Metabolism and Genomics Group, Division of Human Nutrition and Health, Wageningen University, Wageningen, the Netherlands.

Kasper M A Rouschop (K)

Maastricht Radiation Oncology (MaastRO) Laboratory, GROW-School for Oncology and Developmental Biology, Maastricht University Medical Center(+), Maastricht, the Netherlands.

Ellen E Blaak (EE)

Department of Human Biology, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Center(+), Maastricht, the Netherlands.

Gijs H Goossens (GH)

Department of Human Biology, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Center(+), Maastricht, the Netherlands. Electronic address: G.Goossens@maastrichtuniversity.nl.

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Classifications MeSH

questionsmedicales.fr › Phénomènes biologiques › Adaptation biologique › Adaptation physiologique › Mild intermittent hypoxia exposure induces...
questionsmedicales.fr › Tissus › Tissu conjonctif › Tissu adipeux › Mild intermittent hypoxia exposure induces...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Mild intermittent hypoxia exposure induces...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › Mild intermittent hypoxia exposure induces...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Mild intermittent hypoxia exposure induces...
questionsmedicales.fr › États, signes et symptômes pathologiques › Signes et symptômes › Signes et symptômes respiratoires › Hypoxie › Mild intermittent hypoxia exposure induces...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Adulte d'âge moyen › Mild intermittent hypoxia exposure induces...
questionsmedicales.fr › Tissus › Muscles › Muscle strié › Muscles squelettiques › Mild intermittent hypoxia exposure induces...
questionsmedicales.fr › États, signes et symptômes pathologiques › Signes et symptômes › Obésité › Mild intermittent hypoxia exposure induces...
questionsmedicales.fr › Phénomènes physiologiques › Constitution physique › Apparence corporelle › Surpoids › Mild intermittent hypoxia exposure induces...
questionsmedicales.fr › Produits chimiques inorganiques › Gaz › Oxygène › Mild intermittent hypoxia exposure induces...