Aldosterone hyperreactivity to acute psychosocial stress induction in men with essential hypertension.
Acute psychosocial stress
Aldosterone
Cardiovascular hyperreactivity
Essential hypertension
Physiological hyperreactivity
Renin-angiotensin-aldosterone system (RAAS)
TSST
Journal
Hormones and behavior
ISSN: 1095-6867
Titre abrégé: Horm Behav
Pays: United States
ID NLM: 0217764
Informations de publication
Date de publication:
08 2021
08 2021
Historique:
received:
16
02
2021
revised:
20
05
2021
accepted:
10
06
2021
pubmed:
6
7
2021
medline:
3
11
2021
entrez:
5
7
2021
Statut:
ppublish
Résumé
Essential hypertension is a pivotal risk factor for the development of cardiovascular disease (CVD). Hypertensives exhibit greater stress-induced responses in various physiological systems considered to contribute to CVD progression. Whether this stress hyperreactivity extends to the adrenal hormone aldosterone has not yet been investigated in essential hypertension. Here, we investigated reactivity of plasma aldosterone to acute psychosocial stress induction in hypertensive and normotensive men. 21 hypertensive men and 25 normotensive controls underwent the standardized Trier-Social-Stress-Test (TSST). We repeatedly assessed plasma aldosterone before and up to 1 h after TSST cessation. Acute psychosocial stress induced significantly greater increases in hypertensives as compared to normotensives (F(3.60, 158.50) = 3.75; p = .008, f = 0.29). Our findings suggest stress-induced hyperreactivity of aldosterone in essential hypertension. Potential implications for stress-related cardiovascular risk remain to be elucidated.
Identifiants
pubmed: 34224991
pii: S0018-506X(21)00097-0
doi: 10.1016/j.yhbeh.2021.105018
pii:
doi:
Substances chimiques
Aldosterone
4964P6T9RB
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
105018Informations de copyright
Copyright © 2021 Elsevier Inc. All rights reserved.