Polygenic risk scores predict diabetes complications and their response to intensive blood pressure and glucose control.
ADVANCE trial
Cardiovascular complications
Genetics
Polygenic risk score
Prediction
Renal complications
UK Biobank
Journal
Diabetologia
ISSN: 1432-0428
Titre abrégé: Diabetologia
Pays: Germany
ID NLM: 0006777
Informations de publication
Date de publication:
09 2021
09 2021
Historique:
received:
10
12
2020
accepted:
22
03
2021
pubmed:
7
7
2021
medline:
1
4
2022
entrez:
6
7
2021
Statut:
ppublish
Résumé
Type 2 diabetes increases the risk of cardiovascular and renal complications, but early risk prediction could lead to timely intervention and better outcomes. Genetic information can be used to enable early detection of risk. We developed a multi-polygenic risk score (multiPRS) that combines ten weighted PRSs (10 wPRS) composed of 598 SNPs associated with main risk factors and outcomes of type 2 diabetes, derived from summary statistics data of genome-wide association studies. The 10 wPRS, first principal component of ethnicity, sex, age at onset and diabetes duration were included into one logistic regression model to predict micro- and macrovascular outcomes in 4098 participants in the ADVANCE study and 17,604 individuals with type 2 diabetes in the UK Biobank study. The model showed a similar predictive performance for cardiovascular and renal complications in different cohorts. It identified the top 30% of ADVANCE participants with a mean of 3.1-fold increased risk of major micro- and macrovascular events (p = 6.3 × 10 This novel multiPRS model stratified individuals with type 2 diabetes according to risk of complications and helped to target earlier those who would receive greater benefit from intensive therapy.
Identifiants
pubmed: 34226943
doi: 10.1007/s00125-021-05491-7
pii: 10.1007/s00125-021-05491-7
pmc: PMC8382653
doi:
Substances chimiques
Blood Glucose
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2012-2025Subventions
Organisme : British Heart Foundation
ID : CH/1996001/9454
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_PC_17228
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_QA137853
Pays : United Kingdom
Organisme : CIHR
Pays : Canada
Commentaires et corrections
Type : ErratumIn
Informations de copyright
© 2021. The Author(s).
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