Role of VLDL receptor in atherogenesis.
Journal
Current opinion in lipidology
ISSN: 1473-6535
Titre abrégé: Curr Opin Lipidol
Pays: England
ID NLM: 9010000
Informations de publication
Date de publication:
01 08 2021
01 08 2021
Historique:
entrez:
6
7
2021
pubmed:
7
7
2021
medline:
24
2
2022
Statut:
ppublish
Résumé
My group previously discovered and characterized the rabbit and human VLDL receptors. For more than 30 years, I have focused on research regarding the functions of VLDL receptors in the fields of lipoprotein metabolism and atherogenesis. In this review, I introduce the roles of VLDL receptors in lipoprotein metabolism under physiological conditions and in atherogenesis under nonphysiological conditions. I propose that the VLDL receptor plays key roles in the metabolism of postprandial remnant lipoproteins in concert with lipoprotein lipase (LPL). Furthermore, I propound a new mechanism for macrophage foam cell formation via VLDL receptors by remnant lipoproteins and lipoprotein(a) [Lp(a)] in addition to scavenger receptor pathways. The VLDL receptor is a so-called macrophage β-VLDL receptor, which is involved in macrophage foam cell formation by remnant lipoproteins. Furthermore, Lp(a) is a VLDL receptor ligand and is directly taken up through macrophage VLDL receptors for macrophage foam cell formation. Additionally, the roles of VLDL receptors in atherogenesis are canvassed. http://links.lww.com/COL/A21.
Identifiants
pubmed: 34227576
doi: 10.1097/MOL.0000000000000760
pii: 00041433-202108000-00003
doi:
Substances chimiques
Lipoprotein(a)
0
Lipoproteins, VLDL
0
Receptors, LDL
0
VLDL receptor
0
Types de publication
Journal Article
Review
Video-Audio Media
Langues
eng
Sous-ensembles de citation
IM
Pagination
219-225Informations de copyright
Copyright © 2021 Wolters Kluwer Health, Inc. All rights reserved.
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