Two Inhibitors Against the 3C-Like Proteases of Swine Coronavirus and Feline Coronavirus.
3C-like Protease
Coronavirus (CoVs)
Feline infectious peritonitis virus (FIPV)
Inhibitor
Porcine epidemic diarrhoea virus (PEDV)
Journal
Virologica Sinica
ISSN: 1995-820X
Titre abrégé: Virol Sin
Pays: Netherlands
ID NLM: 101514185
Informations de publication
Date de publication:
Dec 2021
Dec 2021
Historique:
received:
19
02
2021
accepted:
06
05
2021
pubmed:
7
7
2021
medline:
24
12
2021
entrez:
6
7
2021
Statut:
ppublish
Résumé
Coronaviruses (CoVs) are important human and animal pathogens that cause respiratory and gastrointestinal diseases. Porcine epidemic diarrhoea (PED), characterized by severe diarrhoea and vomiting in pigs, is a highly lethal disease caused by porcine epidemic diarrhoea virus (PEDV) and causes substantial losses in the swine industry worldwide. However, currently available commercial drugs have not shown great therapeutic effects. In this study, a fluorescence resonance energy transfer (FRET)-based assay was applied to screen a library containing 1,590 compounds and identified two compounds, 3-(aminocarbonyl)-1-phenylpyridinium and 2,3-dichloronaphthoquinone, that target the 3C-like protease (3CL
Identifiants
pubmed: 34228261
doi: 10.1007/s12250-021-00415-6
pii: 10.1007/s12250-021-00415-6
pmc: PMC8258280
doi:
Substances chimiques
Antiviral Agents
0
Coronavirus 3C Proteases
EC 3.4.22.28
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1421-1430Informations de copyright
© 2021. Wuhan Institute of Virology, CAS.
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