Gut Microbiota and Development of Vibrio cholerae-Specific Long-Term Memory B Cells in Adults after Whole-Cell Killed Oral Cholera Vaccine.
Administration, Oral
Adolescent
Adult
Antibody Specificity
/ immunology
B-Lymphocytes
/ immunology
Cholera
/ immunology
Cholera Vaccines
/ administration & dosage
Female
Gastrointestinal Microbiome
Host-Pathogen Interactions
/ immunology
Humans
Immunologic Memory
Male
Microbial Interactions
Vaccination
Vibrio cholerae
/ immunology
Young Adult
Shanchol
gut microbiota
memory B cell response
oral cholera vaccination
Journal
Infection and immunity
ISSN: 1098-5522
Titre abrégé: Infect Immun
Pays: United States
ID NLM: 0246127
Informations de publication
Date de publication:
16 08 2021
16 08 2021
Historique:
pubmed:
7
7
2021
medline:
21
9
2021
entrez:
6
7
2021
Statut:
ppublish
Résumé
Cholera is a diarrheal disease caused by Vibrio cholerae that continues to be a major public health concern in populations without access to safe water. IgG- and IgA-secreting memory B cells (MBC) targeting the V. cholerae O-specific polysaccharide (OSP) correlate with protection from infection in persons exposed to V. cholerae and may be a major determinant of long-term protection against cholera. Shanchol, a widely used oral cholera vaccine (OCV), stimulates OSP MBC responses in only some people after vaccination, and the gut microbiota is a possible determinant of variable immune responses observed after OCV. Using 16S rRNA sequencing of feces from the time of vaccination, we compared the gut microbiota among adults with and without MBC responses to OCV. Gut microbial diversity measures were not associated with MBC isotype or OSP-specific responses, but individuals with a higher abundance of
Identifiants
pubmed: 34228490
doi: 10.1128/IAI.00217-21
pmc: PMC8370679
doi:
Substances chimiques
Cholera Vaccines
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0021721Subventions
Organisme : NIAID NIH HHS
ID : K08 AI123494
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI106878
Pays : United States
Organisme : FIC NIH HHS
ID : D43 TW005572
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI103055
Pays : United States
Organisme : NIAID NIH HHS
ID : R37 AI106878
Pays : United States
Organisme : FIC NIH HHS
ID : K43 TW010362
Pays : United States
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