Hydrogen peroxide toxicity on auditory cells: An in vitro study.

Apoptosis / drug effects Cell Line Cell Survival / drug effects Dose-Response Relationship, Drug Ear, Inner / cytology Humans Hydrogen Peroxide / toxicity Membrane Potential, Mitochondrial / drug effects Oxidative Stress / drug effects Reactive Oxygen Species / metabolism
Cell death Hearing loss Hydrogen peroxide OC-k3 Oxidative stress ROS

Journal

Chemico-biological interactions
ISSN: 1872-7786
Titre abrégé: Chem Biol Interact
Pays: Ireland
ID NLM: 0227276

Informations de publication

Date de publication:
25 Aug 2021
Historique:
received: 01 03 2021
revised: 04 06 2021
accepted: 02 07 2021
pubmed: 7 7 2021
medline: 3 8 2021
entrez: 6 7 2021
Statut: ppublish

Résumé

In recent decades, interest has increased in the role of reactive oxygen species (ROS) in health and disease. The ROS are key causative factors in several hearing loss pathologies including ototoxicity, noise trauma, cochlear ageing and ischemic injury. In order to investigate ROS effects on inner ear cells and counteract them, we developed an in vitro model of oxidative stress by exposing the inner ear cell line OC-k3 to hydrogen peroxide (H

Identifiants

DOI: 10.1016/j.cbi.2021.109575 PMID: 34228970
pubmed: 34228970
pii: S0009-2797(21)00213-1
doi: 10.1016/j.cbi.2021.109575
pii:
doi:

Substances chimiques

Reactive Oxygen Species 0
Hydrogen Peroxide BBX060AN9V

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

109575

Informations de copyright

Copyright © 2021 Elsevier B.V. All rights reserved.

Auteurs

Erica Gentilin (E)

Bioacoustics Research Laboratory, Department of Neurosciences, University of Padua, Padua, Italy. Electronic address: erica.gentilin@unipd.it.

Alice Cani (A)

Department of Woman and Children's Health, University of Padua, Padua, Italy. Electronic address: alice.cani@unipd.it.

Edi Simoni (E)

Bioacoustics Research Laboratory, Department of Neurosciences, University of Padua, Padua, Italy. Electronic address: edi.simoni@unipd.it.

Milvia Chicca (M)

Department of Life Sciences and Biotechnology, University of Ferrara, Ferrara, Italy. Electronic address: milvia.chicca@unife.it.

Maria Luisa Di Paolo (ML)

Department of Molecular Medicine, University of Padua, Italy. Electronic address: marialuisa.dipaolo@unipd.it.

Alessandro Martini (A)

Bioacoustics Research Laboratory, Department of Neurosciences, University of Padua, Padua, Italy; Interdepartmental Research Centre "I-APPROVE - International Auditory Processing Project in Venice", University of Padua, Santi Giovanni e Paolo Hospital, ULSS3 Serenissima, Venice, Italy. Electronic address: alessandromartini@unipd.it.

Laura Astolfi (L)

Bioacoustics Research Laboratory, Department of Neurosciences, University of Padua, Padua, Italy; Interdepartmental Research Centre "I-APPROVE - International Auditory Processing Project in Venice", University of Padua, Santi Giovanni e Paolo Hospital, ULSS3 Serenissima, Venice, Italy. Electronic address: laura.astolfi@unipd.it.

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Classifications MeSH

questionsmedicales.fr › Phénomènes physiologiques cellulaires › Mort cellulaire › Mort cellulaire régulée › Apoptose › Hydrogen peroxide toxicity on auditory cells:...
questionsmedicales.fr › Cellules › Cellules cultivées › Lignée cellulaire › Hydrogen peroxide toxicity on auditory cells:...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Survie cellulaire › Hydrogen peroxide toxicity on auditory cells:...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes toxicologiques › Relation dose-effet des médicaments › Hydrogen peroxide toxicity on auditory cells:...
questionsmedicales.fr › Organes des sens › Oreille › Oreille interne › Hydrogen peroxide toxicity on auditory cells:...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Hydrogen peroxide toxicity on auditory cells:...
questionsmedicales.fr › Composés chimiques organiques › Radicaux libres › Peroxydes › Peroxyde d'hydrogène › Hydrogen peroxide toxicity on auditory cells:...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes électrophysiologiques › Potentiel de membrane mitochondriale › Hydrogen peroxide toxicity on auditory cells:...
questionsmedicales.fr › Phénomènes physiologiques › Stress physiologique › Stress oxydatif › Hydrogen peroxide toxicity on auditory cells:...
questionsmedicales.fr › Produits chimiques inorganiques › Composés de l'oxygène › Espèces réactives de l'oxygène › Hydrogen peroxide toxicity on auditory cells:...