Calcipotriol Enhances Efficacy of Imatinib and Nilotinib on Cells Derived from Plexiform Neurofibroma.
Calcipotriol
NF1
imatinib
nilotinib
plexiform neurofibroma
Journal
Anticancer research
ISSN: 1791-7530
Titre abrégé: Anticancer Res
Pays: Greece
ID NLM: 8102988
Informations de publication
Date de publication:
Jul 2021
Jul 2021
Historique:
received:
05
05
2021
revised:
17
05
2021
accepted:
25
05
2021
entrez:
7
7
2021
pubmed:
8
7
2021
medline:
10
7
2021
Statut:
ppublish
Résumé
Plexiform neurofibromas (PNFs) are benign tumors composed mainly of tumorous Schwann cells and non-tumorous fibroblasts. This study examined the possible enhancing effect of vitamin D on the efficacy of drugs used for the treatment of PNF in vitro. Paired Schwann cells and fibroblasts were cultured from 10 PNFs and treated with imatinib and nilotinib in the absence and presence of calcipotriol, an analogue of the active metabolite of vitamin D. IC Calcipotriol reduced the IC Calcipotriol enhanced the efficacy of imatinib and nilotinib on PNF-derived cells in vitro, though rather non-specifically. Nevertheless, sustaining vitamin D at 100-200 nM, the physiological range, may be beneficial for reducing the dose of drugs without scarifying efficacy.
Sections du résumé
BACKGROUND/AIM
OBJECTIVE
Plexiform neurofibromas (PNFs) are benign tumors composed mainly of tumorous Schwann cells and non-tumorous fibroblasts. This study examined the possible enhancing effect of vitamin D on the efficacy of drugs used for the treatment of PNF in vitro.
MATERIALS AND METHODS
METHODS
Paired Schwann cells and fibroblasts were cultured from 10 PNFs and treated with imatinib and nilotinib in the absence and presence of calcipotriol, an analogue of the active metabolite of vitamin D. IC
RESULTS
RESULTS
Calcipotriol reduced the IC
CONCLUSION
CONCLUSIONS
Calcipotriol enhanced the efficacy of imatinib and nilotinib on PNF-derived cells in vitro, though rather non-specifically. Nevertheless, sustaining vitamin D at 100-200 nM, the physiological range, may be beneficial for reducing the dose of drugs without scarifying efficacy.
Identifiants
pubmed: 34230124
pii: 41/7/3293
doi: 10.21873/anticanres.15116
doi:
Substances chimiques
Pyrimidines
0
Vitamin D
1406-16-2
calcipotriene
143NQ3779B
Imatinib Mesylate
8A1O1M485B
nilotinib
F41401512X
Calcitriol
FXC9231JVH
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
3293-3298Informations de copyright
Copyright © 2021 International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.