Long-chain polyphosphates impair SARS-CoV-2 infection and replication.

Administration, Inhalation Amino Acid Sequence Angiotensin-Converting Enzyme 2 / chemistry Animals Antiviral Agents / administration & dosage COVID-19 / metabolism Caco-2 Cells Chlorocebus aethiops Coronavirus RNA-Dependent RNA Polymerase / chemistry Cytokines / metabolism HEK293 Cells Host Microbial Interactions / drug effects Humans In Vitro Techniques Models, Biological Molecular Docking Simulation Nebulizers and Vaporizers Polyphosphates / administration & dosage Proteasome Endopeptidase Complex / metabolism Protein Interaction Domains and Motifs Proteolysis / drug effects RNA, Viral / genetics SARS-CoV-2 / drug effects Sequence Homology, Amino Acid Signal Transduction / drug effects Vero Cells Virus Replication / drug effects COVID-19 Drug Treatment

Journal

Science signaling

ISSN: 1937-9145

Titre abrégé: Sci Signal

Pays: United States

ID NLM: 101465400

Informations de publication

Date de publication:
06 07 2021

Historique:

entrez: 7 7 2021

pubmed: 8 7 2021

medline: 16 7 2021

Statut: epublish

Résumé

Inorganic polyphosphates (polyPs) are linear polymers composed of repeated phosphate (PO

Identifiants

DOI: 10.1126/scisignal.abe5040 PMID: 34230209 PMC: PMC8432949

pubmed: 34230209

pii: 14/690/eabe5040

doi: 10.1126/scisignal.abe5040

pmc: PMC8432949

pii:

doi:

Substances chimiques

Antiviral Agents 0

Cytokines 0

Polyphosphates 0

RNA, Viral 0

Coronavirus RNA-Dependent RNA Polymerase EC 2.7.7.48

NSP12 protein, SARS-CoV-2 EC 2.7.7.48

ACE2 protein, human EC 3.4.17.23

Angiotensin-Converting Enzyme 2 EC 3.4.17.23

Proteasome Endopeptidase Complex EC 3.4.25.1

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

Informations de copyright

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