One-year persistence of neutralizing anti-SARS-CoV-2 antibodies in dialysis patients recovered from COVID-19.
COVID-19
Sars-CoV-2
antibody
dialysis
immunity
vaccine
Journal
Hemodialysis international. International Symposium on Home Hemodialysis
ISSN: 1542-4758
Titre abrégé: Hemodial Int
Pays: Canada
ID NLM: 101093910
Informations de publication
Date de publication:
10 2021
10 2021
Historique:
received:
09
04
2021
accepted:
20
06
2021
pubmed:
8
7
2021
medline:
21
10
2021
entrez:
7
7
2021
Statut:
ppublish
Résumé
The immunological mechanisms that modulate immune response to SARS-CoV-2 infection remain elusive. Little is known on the magnitude and the durability of antibody response against COVID-19. There is consensus that patients with immune dysfunction, such as dialysis patients, may be unable to mount a robust and durable humoral immunity after infections. Recent studies showed that dialysis patients seroconverted after COVID-19, but data on the durability of the immune response are missing. We reported the data of a durable anti-spike protein seroconversion after natural SARS-CoV-2 infection in three patients on hemodialysis with a mean age of 67.2 ± 13.8 years. A mean antibody titer of 212.6 ± 174.9 UA/ml (Liaison®, DiaSorin) was found after one year (range, 366-374 days) from the diagnosis of COVID-19. In conclusion, this case series provided evidence that patients receiving hemodialysis who recovered from severe COVID-19 were able to mount a long-lasting immune response against SARS-CoV-2. Although the protective capacity of this long-term immunity remains to be determined, these patients did not report signs of reinfection after recovery from COVID-19.
Identifiants
pubmed: 34231319
doi: 10.1111/hdi.12963
pmc: PMC8597126
doi:
Substances chimiques
Antibodies, Viral
0
Types de publication
Case Reports
Langues
eng
Sous-ensembles de citation
IM
Pagination
E53-E56Investigateurs
Cristina Mussini
(C)
Giovanni Guaraldi
(G)
Erica Bacca
(E)
Andrea Bedini
(A)
Vanni Borghi
(V)
Giulia Burastero
(G)
Federica Carli
(F)
Giacomo Ciusa
(G)
Luca Corradi
(L)
Gianluca Cuomo
(G)
Margherita Di Gaetano
(M)
Giovanni Dolci
(G)
Matteo Faltoni
(M)
Riccardo Fantini
(R)
Giacomo Franceschi
(G)
Erica Franceschini
(E)
Vittorio Iadisernia
(V)
Damiano Larné
(D)
Marianna Menozzi
(M)
Marianna Meschiari
(M)
Jovana Milic
(J)
Gabriella Orlando
(G)
Francesco Pellegrino
(F)
Alessandro Raimondi
(A)
Carlotta Rogati
(C)
Antonella Santoro
(A)
Roberto Tonelli
(R)
Marco Tutone
(M)
Sara Volpi
(S)
Dina Yaacoub
(D)
Gianni Cappelli
(G)
Riccardo Magistroni
(R)
Gaetano Alfano
(G)
Francesco Fontana
(F)
Giacomo Mori
(G)
Elisabetta Ascione
(E)
Francesca Damiano
(F)
Silvia Giovanella
(S)
Giulia Ligabue
(G)
Martina Montani
(M)
Niccolò Morisi
(N)
Andrea Melluso
(A)
Monica Frisina
(M)
Camilla Ferri
(C)
Annachiara Ferrari
(A)
Massimo Girardis
(M)
Alberto Andreotti
(A)
Emanuela Biagioni
(E)
Filippo Bondi
(F)
Stefano Busani
(S)
Giovanni Chierego
(G)
Marzia Scotti
(M)
Lucia Serio
(L)
Andrea Cossarizza
(A)
Caterina Bellinazzi
(C)
Rebecca Borella
(R)
Sara De Biasi
(S)
Anna De Gaetano
(A)
Lucia Fidanza
(L)
Lara Gibellini
(L)
Anna Iannone
(A)
Domenico Lo Tartaro
(D)
Marco Mattioli
(M)
Milena Nasi
(M)
Annamaria Paolini
(A)
Marcello Pinti
(M)
Informations de copyright
© 2021 The Authors. Hemodialysis International published by Wiley Periodicals LLC on behalf of International Society for Hemodialysis.
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