Host transcriptional signatures as predictive markers of infection in children.
Journal
Current opinion in infectious diseases
ISSN: 1473-6527
Titre abrégé: Curr Opin Infect Dis
Pays: United States
ID NLM: 8809878
Informations de publication
Date de publication:
01 10 2021
01 10 2021
Historique:
pubmed:
8
7
2021
medline:
15
12
2021
entrez:
7
7
2021
Statut:
ppublish
Résumé
Analyses of the host transcriptional response to infection has proved to be an alternative diagnostic strategy to standard direct pathogen detection. This review summarizes the value of applying blood and mucosal transcriptome analyses for the diagnosis and management of children with viral and bacterial infections. Over the years, studies have validated the concept that RNA transcriptional profiles derived from children with infectious diseases carry a pathogen-specific biosignature that can be qualitatively and quantitively measured. These biosignatures can be translated into a biologically meaningful context to improve patient diagnosis, as seen in children with tuberculosis, rhinovirus infections, febrile infants and children with pneumonia; understand disease pathogenesis (i.e. congenital CMV) and objectively classify patients according to clinical severity (i.e. respiratory syncytial virus). The global assessment of host RNA transcriptional immune responses has improved our understanding of the host-pathogen interactions in the clinical setting. It has shown the potential to be used in clinical situations wherein our current diagnostic tools are inadequate, guiding the diagnosis and classification of children with infectious diseases.
Identifiants
pubmed: 34232136
doi: 10.1097/QCO.0000000000000750
pii: 00001432-202110000-00024
pmc: PMC8446306
mid: NIHMS1719148
doi:
Substances chimiques
Biomarkers
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
552-558Subventions
Organisme : NICHD NIH HHS
ID : R01 HD062477
Pays : United States
Organisme : NICHD NIH HHS
ID : R01 HD085233
Pays : United States
Organisme : NIAID NIH HHS
ID : U01 AI131386
Pays : United States
Informations de copyright
Copyright © 2021 Wolters Kluwer Health, Inc. All rights reserved.
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