Non-bone metastatic cancers promote osteocyte-induced bone destruction.

Animals Apoptosis / genetics Bone Neoplasms / genetics Bone and Bones / metabolism Carcinoma, Lewis Lung / genetics Cathepsin K / genetics Colonic Neoplasms / genetics Female Gene Expression Regulation, Neoplastic / genetics Humans Matrix Metalloproteinase 13 / genetics Mice Neoplasm Metastasis Osteoclasts / metabolism Osteocytes / metabolism Osteolysis / genetics Ovarian Neoplasms / genetics Tartrate-Resistant Acid Phosphatase / genetics Vacuolar Proton-Translocating ATPases / genetics
Bone resorption Cancer cachexia Osteocytes Osteocytic osteolysis

Journal

Cancer letters
ISSN: 1872-7980
Titre abrégé: Cancer Lett
Pays: Ireland
ID NLM: 7600053

Informations de publication

Date de publication:
01 11 2021
Historique:
received: 20 03 2021
revised: 24 06 2021
accepted: 29 06 2021
pubmed: 8 7 2021
medline: 8 1 2022
entrez: 7 7 2021
Statut: ppublish

Résumé

The effects of bone metastatic cancer on the skeleton are well described, whereas less is known regarding the effects of non-metastatic bone cancer on bone. Here we investigated the effects of three non-bone metastatic cancer cachexia models, namely Colon-26 adenocarcinoma (C26), ES-2 ovarian cancer (ES-2), and Lewis lung carcinoma (LLC). Even though C26, ES-2 and LLC tumor growth resulted in comparable weight and muscle loss, the ES-2 and LLC hosts exhibited severe bone loss, whereas only modest bone loss was observed in the C26 bearers, correlating with increased TRAP

Identifiants

DOI: 10.1016/j.canlet.2021.06.030 PMID: 34233150 PMC: PMC8440379
pubmed: 34233150
pii: S0304-3835(21)00324-4
doi: 10.1016/j.canlet.2021.06.030
pmc: PMC8440379
mid: NIHMS1724025
pii:
doi:

Substances chimiques

Acp5 protein, mouse EC 3.1.3.2
Tartrate-Resistant Acid Phosphatase EC 3.1.3.2
Cathepsin K EC 3.4.22.38
Ctsk protein, mouse EC 3.4.22.38
Matrix Metalloproteinase 13 EC 3.4.24.-
Mmp13 protein, mouse EC 3.4.24.-
Atp6v0d2 protein, mouse EC 3.6.1.-
Vacuolar Proton-Translocating ATPases EC 3.6.1.-

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

80-90

Subventions

Organisme : NIAMS NIH HHS
ID : P01 AR046798
Pays : United States
Organisme : NIAMS NIH HHS
ID : T32 AR065971
Pays : United States

Informations de copyright

Copyright © 2021 The Authors. Published by Elsevier B.V. All rights reserved.

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Auteurs

Fabrizio Pin (F)

Department of Anatomy, Cell Biology and Physiology, USA.

Matthew Prideaux (M)

Department of Anatomy, Cell Biology and Physiology, USA.

Joshua R Huot (JR)

Department of Anatomy, Cell Biology and Physiology, USA; Department of Surgery, USA.

Alyson L Essex (AL)

Department of Anatomy, Cell Biology and Physiology, USA.

Lilian I Plotkin (LI)

Department of Anatomy, Cell Biology and Physiology, USA; Indiana Center for Musculoskeletal Health, Indiana University School of Medicine, Indianapolis, IN, USA.

Andrea Bonetto (A)

Department of Anatomy, Cell Biology and Physiology, USA; Department of Surgery, USA; Department of Otolaryngology-Head & Neck Surgery, USA; Simon Comprehensive Cancer Center, USA; Indiana Center for Musculoskeletal Health, Indiana University School of Medicine, Indianapolis, IN, USA.

Lynda F Bonewald (LF)

Department of Anatomy, Cell Biology and Physiology, USA; Simon Comprehensive Cancer Center, USA; Indiana Center for Musculoskeletal Health, Indiana University School of Medicine, Indianapolis, IN, USA. Electronic address: lbonewal@iu.edu.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Non-bone metastatic cancers promote...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Mort cellulaire › Mort cellulaire régulée › Apoptose › Non-bone metastatic cancers promote...
questionsmedicales.fr › Maladies ostéomusculaires › Maladies osseuses › Tumeurs osseuses › Non-bone metastatic cancers promote...
questionsmedicales.fr › Tissus › Tissu conjonctif › Os et tissu osseux › Non-bone metastatic cancers promote...
questionsmedicales.fr › Tumeurs › Carcinome pulmonaire de Lewis › Non-bone metastatic cancers promote...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Peptide hydrolases › Endopeptidases › Cysteine endopeptidases › Cathepsine K › Non-bone metastatic cancers promote...
questionsmedicales.fr › Maladies de l'appareil digestif › Maladies gastro-intestinales › Maladies intestinales › Tumeurs de l'intestin › Tumeurs du côlon › Non-bone metastatic cancers promote...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Régulation de l'expression des gènes tumoraux › Non-bone metastatic cancers promote...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Non-bone metastatic cancers promote...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Secreted matrix metalloproteinases › Matrix Metalloproteinase 13 › Non-bone metastatic cancers promote...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Non-bone metastatic cancers promote...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Processus néoplasiques › Métastase tumorale › Non-bone metastatic cancers promote...
questionsmedicales.fr › Cellules › Cellules myéloïdes › Ostéoclastes › Non-bone metastatic cancers promote...
questionsmedicales.fr › Cellules › Cellules du tissu conjonctif › Ostéoblastes › Ostéocytes › Non-bone metastatic cancers promote...
questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système locomoteur › Résorption osseuse › Ostéolyse › Non-bone metastatic cancers promote...
questionsmedicales.fr › Maladies endocriniennes › Troubles gonadiques › Maladies ovariennes › Tumeurs de l'ovaire › Non-bone metastatic cancers promote...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Phosphoprotein Phosphatases › Tartrate-resistant acid phosphatase › Non-bone metastatic cancers promote...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › Pompes ioniques › Transporteurs de cations › Pompes à protons › Proton-Translocating ATPases › Vacuolar Proton-Translocating ATPases › Non-bone metastatic cancers promote...