Microglia enable mature perineuronal nets disassembly upon anesthetic ketamine exposure or 60-Hz light entrainment in the healthy brain.
60-Hz
anesthesia
ketamine
light entrainment
microglia
ocular dominance plasticity
perineuronal net
Journal
Cell reports
ISSN: 2211-1247
Titre abrégé: Cell Rep
Pays: United States
ID NLM: 101573691
Informations de publication
Date de publication:
06 07 2021
06 07 2021
Historique:
received:
20
08
2020
revised:
20
11
2020
accepted:
04
06
2021
entrez:
7
7
2021
pubmed:
8
7
2021
medline:
11
2
2022
Statut:
ppublish
Résumé
Perineuronal nets (PNNs), components of the extracellular matrix, preferentially coat parvalbumin-positive interneurons and constrain critical-period plasticity in the adult cerebral cortex. Current strategies to remove PNN are long-lasting, invasive, and trigger neuropsychiatric symptoms. Here, we apply repeated anesthetic ketamine as a method with minimal behavioral effect. We find that this paradigm strongly reduces PNN coating in the healthy adult brain and promotes juvenile-like plasticity. Microglia are critically involved in PNN loss because they engage with parvalbumin-positive neurons in their defined cortical layer. We identify external 60-Hz light-flickering entrainment to recapitulate microglia-mediated PNN removal. Importantly, 40-Hz frequency, which is known to remove amyloid plaques, does not induce PNN loss, suggesting microglia might functionally tune to distinct brain frequencies. Thus, our 60-Hz light-entrainment strategy provides an alternative form of PNN intervention in the healthy adult brain.
Identifiants
pubmed: 34233180
pii: S2211-1247(21)00689-6
doi: 10.1016/j.celrep.2021.109313
pmc: PMC8284881
mid: NIHMS1715352
pii:
doi:
Substances chimiques
Anesthetics
0
Parvalbumins
0
Ketamine
690G0D6V8H
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
109313Subventions
Organisme : European Research Council
ID : 715571
Pays : International
Organisme : NEI NIH HHS
ID : R01 EY023037
Pays : United States
Organisme : NEI NIH HHS
ID : R01 EY029245
Pays : United States
Informations de copyright
Copyright © 2021 The Author(s). Published by Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of interests The authors declare no competing interests. A.V. and S.S. disclose an international patent application (PCT/EP2020/079365).
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