No Independent Influence of Statins on the Chronic Obstructive Pulmonary Disease Exacerbation Rate: A Cohort Observation Study Over 10 Years.
chronic obstructive pulmonary disease
death
exacerbation
infection prophylaxis
statins
Journal
International journal of general medicine
ISSN: 1178-7074
Titre abrégé: Int J Gen Med
Pays: New Zealand
ID NLM: 101515487
Informations de publication
Date de publication:
2021
2021
Historique:
received:
05
03
2021
accepted:
10
06
2021
entrez:
8
7
2021
pubmed:
9
7
2021
medline:
9
7
2021
Statut:
epublish
Résumé
Some previously published primarily retrospective studies have shown that statins could reduce the rate and severity of exacerbations, the length of hospital stays, and mortality in patients with chronic obstructive pulmonary disease (COPD), but retrospective data needs to be reviewed regarding this connection since statins are cholesterol-lowering drugs. Therefore, the aim of this study was to investigate the independent influence of statins on the exacerbation rate in COPD patients. An observational retrospective study was conducted to assess the independent influence of statins on the COPD exacerbation rate at the Department of Internal Medicine, Pulmonary Division, Internal Intensive Care Medicine, Infectiology, and Sleep Medicine, Märkische Clinics Health Holding Ltd, Clinic Lüdenscheid, Witten/Herdecke University from January 1, 2010 to December 31, 2020. This study enrolled patients with COPD in 2010 and documented their exacerbation rate over a further 10 years. The number of exacerbations in COPD patients was compared between statin users and non-users. Of the total of 295 [176 male (59.7%)] COPD patients, 105 (35.6%, CI 30.3-41.2%) patients with COPD were treated with statins, and 190 (64.4%, CI 58.8-69.7%) were treated without statins. The mean exacerbation rate in the COPD patients who received statin did not differ from that in the COPD patients who did not receive statin ( Statins have no effect on the exacerbation rate or mortality in COPD patients.
Identifiants
pubmed: 34234518
doi: 10.2147/IJGM.S309647
pii: 309647
pmc: PMC8254092
doi:
Types de publication
Journal Article
Langues
eng
Pagination
2883-2892Informations de copyright
© 2021 Yayan et al.
Déclaration de conflit d'intérêts
Prof. Dr. Karl-Josef Franke report personal fees from Boehringer Ingelheim, personal fees from Glaxo Smith Kline, personal fees from Berlin Chemie, outside the submitted work. The authors confirm no other conflicts of interests in this work.
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