TdP Incidence in Methoxamine-Sensitized Rabbit Model Is Reduced With Age but Not Influenced by Hypercholesterolemia.
TdP arrhythmia
amplitude-aware permutation entropy
arrhythmia risk prediction
hypercholesterolemia
rabbit
Journal
Frontiers in physiology
ISSN: 1664-042X
Titre abrégé: Front Physiol
Pays: Switzerland
ID NLM: 101549006
Informations de publication
Date de publication:
2021
2021
Historique:
received:
09
04
2021
accepted:
17
05
2021
entrez:
8
7
2021
pubmed:
9
7
2021
medline:
9
7
2021
Statut:
epublish
Résumé
Metabolic syndrome is associated with hypercholesterolemia, cardiac remodeling, and increased susceptibility to ventricular arrhythmias. Effects of diet-induced hypercholesterolemia on susceptibility to torsades de pointes arrhythmias (TdP) together with potential indicators of arrhythmic risk were investigated in three experimental groups of Carlsson's rabbit model: (1) young rabbits (YC, young control, age 12-16 weeks), older rabbits (AC, adult control, age 20-24 weeks), and older age-matched cholesterol-fed rabbits (CH, cholesterol, age 20-24 weeks). TdP was induced by α-adrenergic stimulation by methoxamine and I
Identifiants
pubmed: 34234694
doi: 10.3389/fphys.2021.692921
pmc: PMC8255784
doi:
Types de publication
Journal Article
Langues
eng
Pagination
692921Informations de copyright
Copyright © 2021 Nalos, Jarkovská, Švíglerová, Süß, Záleský, Rajdl, Krejčová, Kuncová, Rosenberg and Štengl.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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