The sputum transcriptome better predicts COPD exacerbations after the withdrawal of inhaled corticosteroids than sputum eosinophils.

Journal

ERJ open research
ISSN: 2312-0541
Titre abrégé: ERJ Open Res
Pays: England
ID NLM: 101671641

Informations de publication

Date de publication:
Jul 2021
Historique:
received: 08 02 2021
accepted: 26 04 2021
entrez: 8 7 2021
pubmed: 9 7 2021
medline: 9 7 2021
Statut: epublish

Résumé

Continuing inhaled corticosteroid (ICS) use does not benefit all patients with COPD, yet it is difficult to determine which patients may safely sustain ICS withdrawal. Although eosinophil levels can facilitate this decision, better biomarkers could improve personalised treatment decisions. We performed transcriptional profiling of sputum to explore the molecular biology and compared the predictive value of an unbiased gene signature In multivariate analyses, we identified a gene signature ( We identified a sputum gene expression signature that exhibited a higher predictive value for predicting COPD exacerbations after ICS withdrawal than sputum eosinophilia. Future studies should investigate the utility of this signature, which might enhance personalised ICS treatment in COPD patients.

Identifiants

DOI: 10.1183/23120541.00097-2021 PMID: 34235210 PMC: PMC8255541
pubmed: 34235210
doi: 10.1183/23120541.00097-2021
pii: 00097-2021
pmc: PMC8255541
pii:
doi:

Types de publication

Journal Article

Langues

eng

Subventions

Organisme : NHLBI NIH HHS
ID : K23 HL123778
Pays : United States

Informations de copyright

Copyright ©The authors 2021.

Déclaration de conflit d'intérêts

Conflict of interest: B. Ditz has nothing to disclose. Conflict of interest: A. Sarma reports grants from National Heart, Lung, and Blood Institute, during the conduct of the study. Conflict of interest: H.A.M. Kerstjens reports a grant from AstraZeneca as well as grants and fees for consultancy or advisory board participation from GlaxoSmithKline, Boehringer Ingelheim, and Novartis, and a grant from Chiesi, all outside of the submitted work and all paid to his institution. Conflict of interest: J.J.W. Liesker has nothing to disclose. Conflict of interest: E. Bathoorn has nothing to disclose. Conflict of interest: J.M. Vonk has nothing to disclose. Conflict of interest: V. Bernal has nothing to disclose. Conflict of interest: P. Horvatovich has nothing to disclose. Conflict of interest: V. Guryev has nothing to disclose. Conflict of interest: S. Caldera has nothing to disclose. Conflict of interest: C. Langelier has nothing to disclose. Conflict of interest: A. Faiz has nothing to disclose. Conflict of interest: S.A. Christenson reports consulting fees from AstraZeneca, GlaxoSmithKline, Amgen and Glenmark; personal fees for invited lectures from Sunovion and Genentech; and personal fees for writing for UpToDate, all outside the submitted work. Conflict of interest: M. van den Berge has nothing to disclose.

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Auteurs

Benedikt Ditz (B)

Dept of Pulmonary Diseases, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
University of Groningen, University Medical Center Groningen, Groningen Research Institute for Asthma and COPD, Groningen, The Netherlands.

Aartik Sarma (A)

University of California, San Francisco, CA, USA.

Huib A M Kerstjens (HAM)

Dept of Pulmonary Diseases, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
University of Groningen, University Medical Center Groningen, Groningen Research Institute for Asthma and COPD, Groningen, The Netherlands.
ORCID: 0000-0001-7705-7927

Jeroen J W Liesker (JJW)

Dept of Pulmonary Diseases, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
University of Groningen, University Medical Center Groningen, Groningen Research Institute for Asthma and COPD, Groningen, The Netherlands.

Erik Bathoorn (E)

Dept of Medical Microbiology and Infection Prevention, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.

Judith M Vonk (JM)

University of Groningen, University Medical Center Groningen, Groningen Research Institute for Asthma and COPD, Groningen, The Netherlands.
Dept of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
ORCID: 0000-0001-7531-4547

Victor Bernal (V)

Dept of Analytical Biochemistry, Groningen Research Institute of Pharmacy, Groningen, The Netherlands.

Peter Horvatovich (P)

Dept of Analytical Biochemistry, Groningen Research Institute of Pharmacy, Groningen, The Netherlands.

Victor Guryev (V)

European Research Institute for the Biology of Ageing, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
ORCID: 0000-0002-5810-6022

Saharai Caldera (S)

Division of Infectious Diseases, Dept of Medicine, University of California, San Francisco, CA, USA.
Chan Zuckerberg Biohub, San Francisco, CA, USA.

Chaz Langelier (C)

Division of Infectious Diseases, Dept of Medicine, University of California, San Francisco, CA, USA.
Chan Zuckerberg Biohub, San Francisco, CA, USA.

Alen Faiz (A)

Dept of Pulmonary Diseases, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
University of Groningen, University Medical Center Groningen, Groningen Research Institute for Asthma and COPD, Groningen, The Netherlands.
University of Technology Sydney, Respiratory Bioinformatics and Molecular Biology (RBMB), School of Life Sciences, Sydney, Australia.
These authors contributed equally.

Stephanie A Christenson (SA)

University of California, San Francisco, CA, USA.
These authors contributed equally.

Maarten van den Berge (M)

Dept of Pulmonary Diseases, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
University of Groningen, University Medical Center Groningen, Groningen Research Institute for Asthma and COPD, Groningen, The Netherlands.
These authors contributed equally.

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