Amplicon residues in research laboratories masquerade as COVID-19 in surveillance tests.

Humans COVID-19 / diagnosis SARS-CoV-2 / genetics Laboratories COVID-19 Testing

Journal

Cell reports methods
ISSN: 2667-2375
Titre abrégé: Cell Rep Methods
Pays: United States
ID NLM: 9918227360606676

Informations de publication

Date de publication:
24 05 2021
Historique:
entrez: 8 7 2021
pubmed: 9 7 2021
medline: 9 7 2021
Statut: ppublish

Résumé

Asymptomatic surveillance testing together with COVID-19-related research can lead to positive SARS-CoV-2 tests resulting not from true infections, but non-infectious, non-hazardous by-products of research (amplicons). Amplicons can be widespread and persistent in lab environments and can be difficult to distinguish for true infections. We discuss prevention and mitigation strategies.

Identifiants

DOI: 10.1016/j.crmeth.2021.100005 PMID: 34235497 PMC: PMC8017732
pubmed: 34235497
doi: 10.1016/j.crmeth.2021.100005
pii: S2667-2375(21)00005-9
pmc: PMC8017732
doi:

Types de publication

Introductory Journal Article Research Support, N.I.H., Extramural

Langues

eng

Pagination

100005

Subventions

Organisme : NIGMS NIH HHS
ID : R01 GM120122
Pays : United States

Informations de copyright

© 2021 The Authors.

Références

Science. 2021 Jan 15;371(6526):244-245
pubmed: 33446547
Clin Infect Dis. 2020 Dec 17;71(10):2679-2687
pubmed: 32497212
Lancet Microbe. 2021 Jan;2(1):e13-e22
pubmed: 33521734
Ann Clin Lab Sci. 2004 Autumn;34(4):389-96
pubmed: 15648778
Medicine (Baltimore). 2020 Aug 21;99(34):e21865
pubmed: 32846839

Auteurs

Dan Davidi (D)

Department of Genetics, Harvard Medical School, Boston, MA, USA.

Susan Fitzgerald (S)

Harvard University Health Services, Harvard University, Cambridge, MA, USA.

Hannah L Glaspell (HL)

Biological Safety, Environment, Health and Safety, Cornell University, Ithaca, NY USA.

Samantha Jalbert (S)

Department of Systems Biology, Harvard Medical School, Boston, MA, USA.

Catherine M Klapperich (CM)

Department of Biomedical Engineering and Precision Diagnostics Center, Boston University, Boston, MA 02215.

Lena Landaverde (L)

Department of Biomedical Engineering and Precision Diagnostics Center, Boston University, Boston, MA 02215.

Stylianos Maheras (S)

Harvard University Health Services, Harvard University, Cambridge, MA, USA.

Stephanie E Mattoon (SE)

Biological Safety, Environment, Health and Safety, Cornell University, Ithaca, NY USA.

Vanessa M Britto (VM)

Department of Medicine/University Health Services, Brown University, Providence, RI, USA.

Giang T Nguyen (GT)

Harvard University Health Services, Harvard University, Cambridge, MA, USA.
Department of Medicine, Harvard Medical School, Boston, MA, USA.

Judy T Platt (JT)

Student Health Services, Boston University, Boston, MA, USA.

Kayla Kuhfeldt (K)

Student Health Services, Boston University, Boston, MA, USA.

Hannah Landsberg (H)

Student Health Services, Boston University, Boston, MA, USA.

Cecilia W Stuopis (CW)

MIT Medical, Massachusetts Institute of Technology, Cambridge, MA, USA.

Joshua E Turse (JE)

Biological Safety, Environment, Health and Safety, Cornell University, Ithaca, NY USA.

Davidson H Hamer (DH)

Department of Global Health, Boston University School of Public Health, Boston, MA, USA.
Section of Infectious Diseases, Department of Medicine, Boston University School of Medicine, Boston, MA, USA.
National Emerging Infectious Diseases Laboratory, Boston University, Boston, MA, USA.

Michael Springer (M)

Department of Systems Biology, Harvard Medical School, Boston, MA, USA.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Amplicon residues in research laboratories...
questionsmedicales.fr › Maladies de l'appareil respiratoire › Infections de l'appareil respiratoire › Pneumopathie infectieuse › Pneumopathie virale › COVID-19 › Amplicon residues in research laboratories...
questionsmedicales.fr › Virus › Virus à ARN › Virus à ARN à brin positif › Nidovirales › Coronaviridae › Coronavirus › Betacoronavirus › Virus du SRAS › SARS-CoV-2 › Amplicon residues in research laboratories...
questionsmedicales.fr › Établissements, main d'oeuvre et services de soins de santé › Établissements de santé › Laboratoires › Amplicon residues in research laboratories...
questionsmedicales.fr › Techniques d'investigation › Techniques de laboratoire clinique › Dépistage de la COVID-19 › Amplicon residues in research laboratories...