Dinitrophenol-Hyaluronan Conjugates as Multivalent Antibody-Recruiting Glycopolymers for Targeted Cancer Immunotherapy.
Animals
Antineoplastic Agents
/ chemical synthesis
Cell Proliferation
/ drug effects
Cell Survival
/ drug effects
Cells, Cultured
Dinitrophenols
/ chemistry
Dose-Response Relationship, Drug
Drug Screening Assays, Antitumor
Female
Humans
Hyaluronic Acid
/ chemistry
Immunotherapy
Mammary Neoplasms, Experimental
/ therapy
Mice
Mice, Inbred BALB C
Mice, Nude
Molecular Structure
Polymers
/ chemical synthesis
Structure-Activity Relationship
CD44
Cancer immunotherapy
Dinitrophenol
Hyaluronic acid
Multivalent antibody-recruiting molecules
Journal
ChemMedChem
ISSN: 1860-7187
Titre abrégé: ChemMedChem
Pays: Germany
ID NLM: 101259013
Informations de publication
Date de publication:
06 10 2021
06 10 2021
Historique:
revised:
28
06
2021
received:
06
05
2021
pubmed:
9
7
2021
medline:
19
2
2022
entrez:
8
7
2021
Statut:
ppublish
Résumé
Multivalent antibody-recruiting glycopolymers (MARGs) composed of hyaluronic acid (HA) grafted with multiple copies of dinitrophenol (DNP) were developed for targeted cancer immunotherapy. Structure-activity studies demonstrated that the MARGs were able to specifically recognize CD44-positive cancer cells and displayed remarkable antibody-recruiting capacities and tumor cell killing activities dependent on the introduced multivalent effect and the length of PEG linker. One of the MARGs, HA-[PEG
Identifiants
pubmed: 34235861
doi: 10.1002/cmdc.202100313
doi:
Substances chimiques
Antineoplastic Agents
0
Dinitrophenols
0
Polymers
0
Hyaluronic Acid
9004-61-9
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2960-2968Subventions
Organisme : National Natural Science Foundation of China
ID : 21907038
Organisme : National Natural Science Foundation of China
ID : 32000904
Organisme : China Postdoctoral Science Foundation
ID : BX20200153
Organisme : Natural Science Foundation of Jiangsu Province
ID : BK20200601
Organisme : Health and Family planning Commission of Wuxi
ID : Z202005
Organisme : Jiangnan university
ID : JUSRP12016
Organisme : 111 Project
ID : 111-2-06
Informations de copyright
© 2021 Wiley-VCH GmbH.
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