Loss of MGA repression mediated by an atypical polycomb complex promotes tumor progression and invasiveness.
MAX
MGA
cancer biology
colon organoids
lung adenocarcinoma
mouse
non-canonical polycomb
tumor suppressor
Journal
eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614
Informations de publication
Date de publication:
08 07 2021
08 07 2021
Historique:
received:
24
10
2020
accepted:
24
06
2021
entrez:
8
7
2021
pubmed:
9
7
2021
medline:
23
9
2021
Statut:
epublish
Résumé
MGA, a transcription factor and member of the MYC network, is mutated or deleted in a broad spectrum of malignancies. As a critical test of a tumor suppressive role, we inactivated
Identifiants
pubmed: 34236315
doi: 10.7554/eLife.64212
pii: 64212
pmc: PMC8266391
doi:
pii:
Substances chimiques
Basic Helix-Loop-Helix Transcription Factors
0
Mga protein, mouse
0
Polycomb-Group Proteins
0
Banques de données
GEO
['GSE161606', 'GSE161609', 'GSE161539', 'GSE161541', 'GSE161543', 'GSE175838']
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NCI NIH HHS
ID : R37 CA252050
Pays : United States
Organisme : Cancer Prevention and Research Institute of Texas
ID : RP190385
Organisme : NIH HHS
ID : S10 OD028685
Pays : United States
Organisme : NCI NIH HHS
ID : U01 CA235652
Pays : United States
Organisme : NCI NIH HHS
ID : R50 CA233042
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA054174
Pays : United States
Organisme : NIH HHS
ID : R50 CA233042
Pays : United States
Organisme : Cancer Prevention and Research Institute of Texas
ID : RP160841
Organisme : NCI NIH HHS
ID : R35 CA231989
Pays : United States
Organisme : Cancer Prevention and Research Institute of Texas
ID : RP160487
Organisme : NCI NIH HHS
ID : P50 CA228944
Pays : United States
Organisme : NCI NIH HHS
ID : RO1 CA200547
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA200547
Pays : United States
Informations de copyright
© 2021, Mathsyaraja et al.
Déclaration de conflit d'intérêts
HM, JC, BF, EE, EB, MG, PC, JA, MY, NW, SM, KP, AK, WG, AH, AB, YS, DM No competing interests declared, RE Scientific Advisory Board Member: Kronos Bio Inc.; Shenogen Pharma Beijing. No overlap with the present study.
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