What can be done to control the placebo response in clinical trials? A narrative review.
Expectation measurements
Placebo effect
Placebo response
Randomized controlled trials
Training
Journal
Contemporary clinical trials
ISSN: 1559-2030
Titre abrégé: Contemp Clin Trials
Pays: United States
ID NLM: 101242342
Informations de publication
Date de publication:
08 2021
08 2021
Historique:
received:
10
03
2021
revised:
30
06
2021
accepted:
01
07
2021
pubmed:
9
7
2021
medline:
25
9
2021
entrez:
8
7
2021
Statut:
ppublish
Résumé
The desire to reduce high placebo response rates in clinical trials is a popular concept. However, few studies have rigorously examined the effectiveness of methods to control for placebo responses that are relevant to randomized controlled trials. The primary objective of this review was to evaluate the effect of experimental placebo manipulations in randomized controlled trials (RCTs). We critically reviewed studies designed to manipulate placebo responses including positive expectations regarding the effectiveness of the placebo treatment, manipulating the time spent with subjects, and training study staff and subjects to accurately report symptom severity. These efforts have generally resulted in reduced placebo response and improved discrimination between drug and placebo. Interventions that neutralize staff and subject expectations and improve the ability of subjects to accurately report symptom severity have shown the most promise. Reduction of the placebo response has the potential to accelerate the development of new therapeutics.
Identifiants
pubmed: 34237458
pii: S1551-7144(21)00239-1
doi: 10.1016/j.cct.2021.106503
pmc: PMC8719632
mid: NIHMS1737650
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
106503Subventions
Organisme : NCCIH NIH HHS
ID : R01 AT010333
Pays : United States
Organisme : NCCIH NIH HHS
ID : R01 AT011347
Pays : United States
Organisme : NIDCR NIH HHS
ID : R01 DE025946
Pays : United States
Informations de copyright
Copyright © 2021 Elsevier Inc. All rights reserved.
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