Podocyte-derived microparticles in IgA nephropathy.
Ectosome
IgA nephropathy
Microparticle
Microvesicle
Podocyte
Journal
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
ISSN: 1950-6007
Titre abrégé: Biomed Pharmacother
Pays: France
ID NLM: 8213295
Informations de publication
Date de publication:
Sep 2021
Sep 2021
Historique:
received:
03
03
2021
revised:
06
06
2021
accepted:
28
06
2021
pubmed:
9
7
2021
medline:
16
12
2021
entrez:
8
7
2021
Statut:
ppublish
Résumé
Microparticles are a general term for different types of cell plasma membrane-originated vesicles that are released into the extracellular environment. The paracrine action of these nano-sized vesicles is crucial for intercellular communications through the transfer of diverse lipids, cytosolic proteins, RNA as well as microRNAs. The progression of different diseases influences the composition, occurrence, and functions of these cell-derived particles. Podocyte injury has been shown to have an important role in the pathophysiology of many glomerular diseases including IgA nephropathy (IgAN). This review would focus on the possible potential of podocyte-derived microparticles detected in urine to be used as a diagnostic tool in IgAN.
Identifiants
pubmed: 34237594
pii: S0753-3322(21)00673-9
doi: 10.1016/j.biopha.2021.111891
pii:
doi:
Substances chimiques
MicroRNAs
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
111891Informations de copyright
Copyright © 2021 The Authors. Published by Elsevier Masson SAS.. All rights reserved.