c-FLIP regulates autophagy by interacting with Beclin-1 and influencing its stability.
Animals
Autophagy
Beclin-1
/ metabolism
CASP8 and FADD-Like Apoptosis Regulating Protein
/ genetics
Fibroblasts
/ metabolism
HEK293 Cells
Humans
Mice
Molecular Docking Simulation
Nedd4 Ubiquitin Protein Ligases
/ metabolism
Proteasome Endopeptidase Complex
/ metabolism
Protein Binding
Protein Stability
Ubiquitination
Journal
Cell death & disease
ISSN: 2041-4889
Titre abrégé: Cell Death Dis
Pays: England
ID NLM: 101524092
Informations de publication
Date de publication:
08 07 2021
08 07 2021
Historique:
received:
22
02
2021
accepted:
15
06
2021
revised:
14
06
2021
entrez:
9
7
2021
pubmed:
10
7
2021
medline:
22
9
2021
Statut:
epublish
Résumé
c-FLIP (cellular FLICE-like inhibitory protein) protein is mostly known as an apoptosis modulator. However, increasing data underline that c-FLIP plays multiple roles in cellular homoeostasis, influencing differently the same pathways depending on its expression level and isoform predominance. Few and controversial data are available regarding c-FLIP function in autophagy. Here we show that autophagic flux is less effective in c-FLIP-/- than in WT MEFs (mouse embryonic fibroblasts). Indeed, we show that the absence of c-FLIP compromises the expression levels of pivotal factors in the generation of autophagosomes. In line with the role of c-FLIP as a scaffold protein, we found that c-FLIP
Identifiants
pubmed: 34238932
doi: 10.1038/s41419-021-03957-5
pii: 10.1038/s41419-021-03957-5
pmc: PMC8266807
doi:
Substances chimiques
Beclin-1
0
Becn1 protein, mouse
0
CASP8 and FADD-Like Apoptosis Regulating Protein
0
Cflar protein, mouse
0
Nedd4 Ubiquitin Protein Ligases
EC 2.3.2.26
Nedd4 protein, mouse
EC 2.3.2.26
Proteasome Endopeptidase Complex
EC 3.4.25.1
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
686Références
EMBO J. 2015 Apr 1;34(7):856-80
pubmed: 25712477
J Cell Sci. 2017 Nov 15;130(22):3839-3850
pubmed: 29021346
Genes Dev. 2007 Nov 15;21(22):2861-73
pubmed: 18006683
Int J Mol Sci. 2017 Jun 15;18(6):
pubmed: 28617309
Cells. 2012 Aug 02;1(3):428-48
pubmed: 24710484
Autophagy. 2008 Oct;4(7):929-31
pubmed: 18719356
Immunity. 2000 Jun;12(6):633-42
pubmed: 10894163
Mol Biol Cell. 2008 Dec;19(12):5360-72
pubmed: 18843052
J Hypertens. 2008 May;26(5):1008-16
pubmed: 18398344
Nat Cell Biol. 2009 Apr;11(4):385-96
pubmed: 19270696
Autophagy. 2016;12(3):547-64
pubmed: 27046250
BMB Rep. 2016 Aug;49(8):424-30
pubmed: 27418283
Nature. 2007 Jun 28;447(7148):1121-5
pubmed: 17589504
J Hepatol. 2011 Dec;55(6):1272-80
pubmed: 21703207
Biochem J. 2012 Jan 1;441(1):399-406
pubmed: 21936852
Nat Cell Biol. 2013 Apr;15(4):406-16
pubmed: 23524951
Proc Natl Acad Sci U S A. 2008 Oct 28;105(43):16677-82
pubmed: 18946037
Semin Cancer Biol. 2020 Nov;66:116-128
pubmed: 31838023
Biomed Pharmacother. 2018 Aug;104:485-495
pubmed: 29800913
EMBO J. 2012 Nov 14;31(22):4304-17
pubmed: 23064152
Cell Death Dis. 2019 Dec 2;10(12):904
pubmed: 31787758
FEBS J. 2018 Nov;285(22):4104-4123
pubmed: 29806737
Nature. 1997 Apr 3;386(6624):517-21
pubmed: 9087414
FEBS J. 2020 Oct;287(19):4246-4260
pubmed: 32096279
J Biol Chem. 2018 Apr 13;293(15):5386-5395
pubmed: 29371398
Mol Cell Biol. 2002 Aug;22(15):5419-33
pubmed: 12101236
Nat Cell Biol. 2011 Feb;13(2):132-41
pubmed: 21258367
J Cell Sci. 2017 Apr 1;130(7):1209-1216
pubmed: 28302910
Exp Cell Res. 2012 Jul 1;318(11):1324-31
pubmed: 22309778
PLoS One. 2013 Nov 26;8(11):e80317
pubmed: 24303007
Nat Cell Biol. 2018 May;20(5):521-527
pubmed: 29686264
Trends Cell Biol. 1998 Oct;8(10):397-403
pubmed: 9789328
Oxid Med Cell Longev. 2018 Jan 31;2018:8023821
pubmed: 29643976
Cell Death Differ. 2015 Jul;22(7):1131-43
pubmed: 25501600
Cell Death Differ. 2008 Apr;15(4):773-82
pubmed: 18219316
Cell Death Dis. 2010 Apr 29;1:e38
pubmed: 21364645
Cell Signal. 2016 Sep;28(9):1262-9
pubmed: 27267061
FASEB J. 2006 Jan;20(1):124-6
pubmed: 16263940
Autophagy. 2021 Jan;17(1):1-382
pubmed: 33634751
J Biol Chem. 2005 Jul 15;280(28):26089-93
pubmed: 15905173
Proc Natl Acad Sci U S A. 2009 May 19;106(20):8169-74
pubmed: 19416807
Proc Natl Acad Sci U S A. 2003 Dec 9;100(25):15077-82
pubmed: 14657337
J Cell Biol. 2010 Aug 9;190(3):377-89
pubmed: 20696707
Nature. 1997 Jul 10;388(6638):190-5
pubmed: 9217161
Cancers (Basel). 2018 Jan 12;10(1):
pubmed: 29329237
Nutrients. 2019 Apr 11;11(4):
pubmed: 30979078
Cell Death Dis. 2010;1:e18
pubmed: 21364619
J BUON. 2019 Mar-Apr;24(2):634-641
pubmed: 31128017
J Mol Biol. 1991 Jul 20;220(2):507-30
pubmed: 1856871
Int J Mol Sci. 2017 Nov 27;18(12):
pubmed: 29186924
Cell Res. 2012 Mar;22(3):473-89
pubmed: 22310240
Curr Biol. 2000 Jun 1;10(11):640-8
pubmed: 10837247
Lancet Neurol. 2018 Sep;17(9):802-815
pubmed: 30129476
J Cell Sci. 2015 Jan 15;128(2):193-205
pubmed: 25568151
Cell Death Differ. 2018 Mar;25(3):486-541
pubmed: 29362479
Cell Rep. 2020 Feb 25;30(8):2807-2819.e4
pubmed: 32101753
Autophagy. 2017;13(12):2041-2055
pubmed: 29251248
Int J Biochem Cell Biol. 2009 Aug-Sep;41(8-9):1678-84
pubmed: 19433309
Nat Cell Biol. 2009 Nov;11(11):1355-62
pubmed: 19838173
Oxid Med Cell Longev. 2018 Dec 2;2018:1471682
pubmed: 30622661