A momentary assessment study on emotional and biological stress in adult males and females with autism spectrum disorder.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
08 07 2021
08 07 2021
Historique:
received:
27
02
2021
accepted:
09
06
2021
entrez:
9
7
2021
pubmed:
10
7
2021
medline:
3
11
2021
Statut:
epublish
Résumé
Prospective momentary psychological and biological measures of real-time daily life stress experiences have been examined in several psychiatric disorders, but not in adults with an autism spectrum disorder (ASD). The current electronic self-monitoring study examined associations between momentary daily life stressors and (i) negative affect (NA; emotional stress reactivity) and (ii) cortisol levels (biological stress reactivity) in males and females with ASD (N = 50) and without ASD (N = 51). The Experience Sampling Method, including saliva sampling, was used to measure three types of daily life stress (activity-related, event-related, and social stress), NA, and cortisol. Multilevel regression analyses demonstrated significant interactions between group and stress (i.e., activity-related and event-related stress) in the model of NA, indicating stronger emotional stress reactivity in the ASD than in the control group. In the model of cortisol, none of the group × stress interactions were significant. Male/female sex had no moderating effect on either emotional or biological stress reactivity. In conclusion, adults with ASD showed a stronger emotional stress (but not cortisol) reactivity in response to unpleasant daily life events and activities. The findings highlight the feasibility of electronic self-monitoring in individuals with ASD, which may contribute to the development of more personalized stress-management approaches.
Identifiants
pubmed: 34238944
doi: 10.1038/s41598-021-93159-y
pii: 10.1038/s41598-021-93159-y
pmc: PMC8266874
doi:
Substances chimiques
Hydrocortisone
WI4X0X7BPJ
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
14160Références
Bishop-Fitzpatrick, L., Minshew, N. J., Mazefsky, C. A. & Eack, S. M. Perception of life as stressful, not biological response to stress, is associated with greater social disability in adults with autism spectrum disorder. J. Autism Dev. Disord. 47, 1–16 (2017).
pubmed: 27696184
pmcid: 5225258
doi: 10.1007/s10803-016-2910-6
Hirvikoski, T. & Blomqvist, M. High self-perceived stress and poor coping in intellectually able adults with autism spectrum disorder. Autism 19, 752–757 (2015).
pubmed: 25073750
doi: 10.1177/1362361314543530
van der Steen, Y. et al. Clinical high risk for psychosis: The association between momentary stress, affective and psychotic symptoms. Acta Psychiatr. Scand. 136, 63–73 (2017).
pubmed: 28260264
doi: 10.1111/acps.12714
Myin-Germeys, I., van Os, J., Schwartz, J. E., Stone, A. A. & Delespaul, P. A. Emotional reactivity to daily life stress in psychosis. Arch. Gen. Psychiatry 58, 1137–1144 (2001).
pubmed: 11735842
doi: 10.1001/archpsyc.58.12.1137
Havermans, R., Nicolson, N. A., Berkhof, J. & de Vries, M. W. Mood reactivity to daily events in patients with remitted bipolar disorder. Psychiatry Res. 179, 47–52 (2010).
pubmed: 20478632
doi: 10.1016/j.psychres.2009.10.020
Corbett, B. A., Muscatello, R. A. & Blain, S. D. Impact of sensory sensitivity on physiological stress response and novel peer interaction in children with and without autism spectrum disorder. Front. Neurosci. 10, 278 (2016).
pubmed: 27445653
pmcid: 4917546
doi: 10.3389/fnins.2016.00278
Schupp, C. W., Simon, D. & Corbett, B. A. Cortisol responsivity differences in children with autism spectrum disorders during free and cooperative play. J. Autism Dev. Disord. 43, 2405–2417 (2013).
pubmed: 23430177
doi: 10.1007/s10803-013-1790-2
Hollocks, M. J., Howlin, P., Papadopoulos, A. S., Khondoker, M. & Simonoff, E. Differences in HPA-axis and heart rate responsiveness to psychosocial stress in children with autism spectrum disorders with and without co-morbid anxiety. Psychoneuroendocrinology 46, 32–45 (2014).
pubmed: 24882156
doi: 10.1016/j.psyneuen.2014.04.004
Levine, T. P. et al. Physiologic arousal to social stress in children with autism spectrum disorders: A pilot study. Res. Autism Spectr. Disord. 6, 177–183 (2012).
pubmed: 22081773
pmcid: 3212393
doi: 10.1016/j.rasd.2011.04.003
Corbett, B. A. et al. Biobehavioral profiles of arousal and social motivation in autism spectrum disorders. J. Child Psychol. Psychiatry 55, 924–934 (2014).
pubmed: 24329926
doi: 10.1111/jcpp.12184
Corbett, B. A., Muscatello, R. A. & Baldinger, C. Comparing stress and arousal systems in response to different social contexts in children with ASD. Biol. Psychol. 140, 119–130 (2019).
pubmed: 30557600
doi: 10.1016/j.biopsycho.2018.12.010
Smeekens, I., Didden, R. & Verhoeven, E. Exploring the relationship of autonomic and endocrine activity with social functioning in adults with autism spectrum disorders. J. Autism Dev. Disord. 45, 495–505 (2015).
pubmed: 24062183
doi: 10.1007/s10803-013-1947-z
Jacobs, N. et al. A momentary assessment study of the relationship between affective and adrenocortical stress responses in daily life. Biol. Psychol. 74, 60–66 (2007).
pubmed: 16942831
doi: 10.1016/j.biopsycho.2006.07.002
Collip, D. et al. Daily cortisol, stress reactivity and psychotic experiences in individuals at above average genetic risk for psychosis. Psychol. Med. 41, 2305–2315 (2011).
pubmed: 21733219
doi: 10.1017/S0033291711000602
van Duin, E. D. A. et al. Lower cortisol levels and attenuated cortisol reactivity to daily-life stressors in adults with 22q11.2 deletion syndrome. Psychoneuroendocrinology 106, 85–94 (2019).
pubmed: 30959234
doi: 10.1016/j.psyneuen.2019.03.023
Oldehinkel, A. J. & Bouma, E. M. Sensitivity to the depressogenic effect of stress and HPA-axis reactivity in adolescence: A review of gender differences. Neurosci. Biobehav. Rev. 35, 1757–1770 (2011).
pubmed: 21040743
doi: 10.1016/j.neubiorev.2010.10.013
McEwen, B. S. Protection and damage from acute and chronic stress: Allostasis and allostatic overload and relevance to the pathophysiology of psychiatric disorders. Ann. N. Y. Acad. Sci. 1032, 1–7 (2004).
pubmed: 15677391
doi: 10.1196/annals.1314.001
Qin, D. D. et al. Prolonged secretion of cortisol as a possible mechanism underlying stress and depressive behaviour. Sci. Rep. 6, 1–9 (2016).
Cohen, H. et al. Blunted HPA axis response to stress influences susceptibility to posttraumatic stress response in rats. Biol. Psychiatry. 59, 1208–1218 (2006).
pubmed: 16458266
doi: 10.1016/j.biopsych.2005.12.003
Frye, C. A. & Llaneza, D. C. Corticosteroid and neurosteroid dysregulation in an animal model of autism, BTBR mice. Physiol. Behav. 100, 264–267 (2010).
pubmed: 20298706
pmcid: 2860004
doi: 10.1016/j.physbeh.2010.03.005
Benno, R., Smirnova, Y., Vera, S., Liggett, A. & Schanz, N. Exaggerated responses to stress in the BTBR T+tf/J mouse: An unusual behavioral phenotype. Behav. Brain Res. 197, 462–465 (2009).
pubmed: 18977396
doi: 10.1016/j.bbr.2008.09.041
Kessler, R. C., McGonagle, K. A., Swartz, M., Blazer, D. G. & Nelson, C. B. Sex and depression in the National Comorbidity Survey I: Lifetime prevalence, chronicity and recurrence. J. Affect. Disord. 29, 85–96 (1993).
pubmed: 8300981
doi: 10.1016/0165-0327(93)90026-G
Marcus, S. M. et al. Gender differences in depression: Findings from the STAR*D study. J. Affect. Disord. 87, 141–150 (2005).
pubmed: 15982748
doi: 10.1016/j.jad.2004.09.008
Bangasser, D. A. et al. Sex differences in corticotropin-releasing factor receptor signaling and trafficking: Potential role in female vulnerability to stress-related psychopathology. Mol. Psychiatry. 15, 896–904 (2010).
doi: 10.1038/mp.2010.66
McGillivray, J. A. & Evert, H. T. Exploring the effect of gender and age on stress and emotional distress in adults with autism spectrum disorder. Focus Autism Other Dev. Disabil. 33, 55–64 (2018).
doi: 10.1177/1088357614549317
Myin-Germeys, I., Krabbendam, L., Delespaul, P. & Van Os, J. Sex differences in emotional reactivity to daily life stress in psychosis. J. Clin. Psychiatry 65, 805–809 (2004).
pubmed: 15291657
doi: 10.4088/JCP.v65n0611
King, B. H. & Lord, C. Is schizophrenia on the autism spectrum?. Brain Res. 1380, 34–41 (2011).
pubmed: 21078305
doi: 10.1016/j.brainres.2010.11.031
Owen, M. J. & O’Donovan, M. C. Schizophrenia and the neurodevelopmental continuum: Evidence from genomics. World Psychiatry 16, 227–235 (2017).
pubmed: 28941101
pmcid: 5608820
doi: 10.1002/wps.20440
McLaughlin, K. A. et al. Childhood social environment, emotional reactivity to stress, and mood and anxiety disorders across the life course. Depress. Anxiety. 27, 1087–1094 (2010).
pubmed: 21132844
pmcid: 3074636
doi: 10.1002/da.20762
Susman, E. J., Dorn, L. D., Inoff-Germain, G., Nottelmann, E. D. & Chrousos, G. P. Cortisol reactivity, distress behavior, and behavioral and psychological problems in young adolescents: A longitudinal perspective. J. Res. Adolesc. 7, 81–105 (1997).
doi: 10.1207/s15327795jra0701_5
Csikszentmihalyi, M. & Larson, R. Flow and the Foundations of Positive Psychology 35–54 (Springer, 2014).
doi: 10.1007/978-94-017-9088-8
Myin-Germeys, I. et al. Experience sampling research in psychopathology: Opening the black box of daily life. Psychol. Med. 39, 1533–1547 (2009).
pubmed: 19215626
doi: 10.1017/S0033291708004947
Chen, Y.-W., Bundy, A., Cordier, R. & Einfeld, S. Feasibility and usability of experience sampling methodology for capturing everyday experiences of individuals with autism spectrum disorders. Disabil. Health J. 7, 361–366 (2014).
pubmed: 24947579
doi: 10.1016/j.dhjo.2014.04.004
Kovac, M., Mosner, M., Miller, S., Hanna, E. K. & Dichter, G. S. Experience sampling of positive affect in adolescents with autism: Feasibility and preliminary findings. Res. Autism Spectr. Disord. 29, 57–65 (2016).
pubmed: 28083073
doi: 10.1016/j.rasd.2016.06.003
Vaessen, T. et al. Stress assessment using experience sampling: convergent validity and clinical relevance. Stress Self-assess. Questionnaires Choice Appl. Limits, 21–35 (2015).
Myin-Germeys, I. et al. Emotional reactivity to daily life stress in psychosis and affective disorder: An experience sampling study. Acta Psychiatr. Scand. 107, 124–131 (2003).
pubmed: 12534438
doi: 10.1034/j.1600-0447.2003.02025.x
Reininghaus, U. et al. Stress sensitivity, aberrant salience, and threat anticipation in early psychosis: An experience sampling study. Schizophr. Bull. 42, 712–717 (2016).
pubmed: 26834027
pmcid: 4838104
doi: 10.1093/schbul/sbv190
Gantman, A., Kapp, S. K., Orenski, K. & Laugeson, E. A. Social skills training for young adults with high-functioning autism spectrum disorders: A randomized controlled pilot study. J. Autism Dev. Disord. 42, 1094–1103 (2012).
pubmed: 21915740
doi: 10.1007/s10803-011-1350-6
Renty, J. & Roeyers, H. Individual and marital adaptation in men with autism spectrum disorder and their spouses: The role of social support and coping strategies. J. Autism Dev. Disord. 37, 1247–1255 (2007).
pubmed: 17080274
doi: 10.1007/s10803-006-0268-x
Brailovskaia, J. et al. A cross-cultural study in Germany, Russia, and China: Are resilient and social supported students protected against depression, anxiety, and stress?. Psychol. Rep. 121, 265–281 (2018).
pubmed: 28836915
doi: 10.1177/0033294117727745
Lugnegård, T., Hallerbäck, M. U. & Gillberg, C. Psychiatric comorbidity in young adults with a clinical diagnosis of Asperger syndrome. Res. Develop. Disabil. 32, 1910–1917 (2011).
doi: 10.1016/j.ridd.2011.03.025
Lai, M.-C. et al. A behavioral comparison of male and female adults with high functioning autism spectrum conditions. PLoS ONE 6, 6 (2011).
doi: 10.1371/journal.pone.0020835
Carpenter, T., Grecian, S. & Reynolds, R. Sex differences in early-life programming of the hypothalamic–pituitary–adrenal axis in humans suggest increased vulnerability in females: A systematic review. J. Dev. Origins Health Dis. 8, 244–255 (2017).
doi: 10.1017/S204017441600074X
Vaessen, T. et al. Overall cortisol, diurnal slope, and stress reactivity in psychosis: An experience sampling approach. Psychoneuroendocrinology 96, 61–68 (2018).
pubmed: 29906787
doi: 10.1016/j.psyneuen.2018.06.007
Schlotz, W. et al. Covariance between psychological and endocrine responses to pharmacological challenge and psychosocial stress: A question of timing. Psychosom. Med. 70, 787–796 (2008).
pubmed: 18725434
doi: 10.1097/PSY.0b013e3181810658
Schlotz, W. Investigating associations between momentary stress and cortisol in daily life: What have we learned so far?. Psychoneuroendocrinology 105, 105–116 (2019).
pubmed: 30503527
doi: 10.1016/j.psyneuen.2018.11.038
Nicolson, N. A. Handbook of Physiological Research Methods in Health Psychology 37–74 (Sage Publications, 2008).
doi: 10.4135/9781412976244.n3
Mohammed, T.-E., Christian, R., Brendan, O. F. & Paul, G. A review of wearable solutions for physiological and emotional monitoring for use by people with autism spectrum disorder and their caregivers. Sensors 18, 4271 (2018).
doi: 10.3390/s18124271
Sekar, M. et al. Review—Towards wearable sensor platforms for the electrochemical detection of cortisol. J. Electrochem. Soc. 167, 067508 (2020).
doi: 10.1149/1945-7111/ab7e24
Lackschewitz, H., Hüther, G. & Kröner-Herwig, B. Physiological and psychological stress responses in adults with attention-deficit/hyperactivity disorder (ADHD). Psychoneuroendocrinology 33, 612–624 (2008).
pubmed: 18329819
doi: 10.1016/j.psyneuen.2008.01.016
Corominas-Roso, M. et al. Cortisol response to stress in adults with attention deficit hyperactivity disorder. Int. J. Neuropsychopharmacol. 18, 1–10 (2015).
doi: 10.1093/ijnp/pyv027
Martin, J. et al. Biological overlap of attention-deficit/hyperactivity disorder and autism spectrum disorder: Evidence from copy number variants. J. Am. Acad. Child Adolesc. Psychiatry 53, 761–770 (2014).
pubmed: 24954825
pmcid: 4074351
doi: 10.1016/j.jaac.2014.03.004
Ronald, A., Simonoff, E., Kuntsi, J., Asherson, P. & Plomin, R. Evidence for overlapping genetic influences on autistic and ADHD behaviours in a community twin sample. J. Child Psychol. Psychiatry 49, 535–542 (2008).
pubmed: 18221348
doi: 10.1111/j.1469-7610.2007.01857.x
Buck, T. R. et al. Psychiatric comorbidity and medication use in adults with autism spectrum disorder. J. Autism Dev. Disord. 44, 3063–3071 (2014).
pubmed: 24958436
pmcid: 4355011
doi: 10.1007/s10803-014-2170-2
Joshi, G. et al. Psychiatric comorbidity and functioning in a clinically referred population of adults with autism spectrum disorders: A comparative study. J. Autism Dev. Disord. 43, 1314–1325 (2013).
pubmed: 23076506
doi: 10.1007/s10803-012-1679-5
van Winkel, M. et al. Daily life stress reactivity in remitted versus non-remitted depressed individuals. Eur. Psychiatry 30, 441–447 (2015).
pubmed: 25891263
doi: 10.1016/j.eurpsy.2015.02.011
Myin-Germeys, I. et al. Emotional reactivity to daily life stress in psychosis and affective disorder: An experience sampling study emotional reactivity. Acta Psychiatr. Scand. 107, 124–131 (2003).
pubmed: 12534438
doi: 10.1034/j.1600-0447.2003.02025.x
Corbett, B. A., Schupp, C. W., Simon, D., Ryan, N. & Mendoza, S. Elevated cortisol during play is associated with age and social engagement in children with autism. Mol. Autism 1, 13 (2010).
pubmed: 20875126
pmcid: 2955575
doi: 10.1186/2040-2392-1-13
Lord, C. et al. In Autism Diagnostic Observation Schedule Second Edition (ADOS-2) Manual (Part 1): Modules 1–4 (Western Psychological Services, 2012).
Lecrubier, Y. et al. The Mini International Neuropsychiatric Interview (MINI). A short diagnostic structured interview: Reliability and validity according to the CIDI. Eur. Psychiatry 12, 224–231 (1997).
doi: 10.1016/S0924-9338(97)83296-8
Baron-Cohen, S., Wheelwright, S., Skinner, R., Martin, J. & Clubley, E. The autism-spectrum quotient (AQ): Evidence from asperger syndrome/high-functioning autism, malesand females, scientists and mathematicians. J. Autism Dev. Disord. 31, 5–17 (2001).
pubmed: 11439754
doi: 10.1023/A:1005653411471
Woodbury-Smith, M. R., Robinson, J., Wheelwright, S. & Baron-Cohen, S. Screening adults for Asperger syndrome using the AQ: A preliminary study of its diagnostic validity in clinical practice. J. Autism Dev. Disord. 35, 331–335 (2005).
pubmed: 16119474
doi: 10.1007/s10803-005-3300-7
Wechsler, D. In Wechsler Adult Intelligence Scale–Fourth Edition (WAIS–IV). (The Psychological Corporation, 2008).
van der Linden, K., Simons, C., van Amelsvoort, T. & Marcelis, M. Lifetime and momentary psychotic experiences in adult males and females with an autism spectrum disorder. Front. Psychiatry 11, 766–777 (2020).
pubmed: 32848936
pmcid: 7416642
doi: 10.3389/fpsyt.2020.00766
Delespaul, P. Assessing Schizophrenia in Daily Life: The Experience Sampling Method (Maastricht University, 1995).
Wichers, M., Lothmann, C., Simons, C. J., Nicolson, N. A. & Peeters, F. The dynamic interplay between negative and positive emotions in daily life predicts response to treatment in depression: A momentary assessment study. Br. J. Clin. Psychol. 51, 206–222 (2012).
pubmed: 22574805
doi: 10.1111/j.2044-8260.2011.02021.x
Kasanova, Z., Hajdúk, M., Thewissen, V. & Myin-Germeys, I. Temporal associations between sleep quality and paranoia across the paranoia continuum: An experience sampling study. J. Abnormal. Psychol. 129, 122–130 (2020).
doi: 10.1037/abn0000453
Watson, D., Clark, L. A. & Tellegen, A. Development and validation of brief measures of positive and negative affect: The PANAS scales. J. Pers. Soc. Psychol. 54, 1063–1070 (1988).
pubmed: 3397865
doi: 10.1037/0022-3514.54.6.1063
Dressendörfer, R., Kirschbaum, C., Rohde, W., Stahl, F. & Strasburger, C. Synthesis of a cortisol-biotin conjugate and evaluation as a tracer in an immunoassay for salivary cortisol measurement. J. Steroid Biochem. Mol. Biol. 43, 683–692 (1992).
pubmed: 1472460
doi: 10.1016/0960-0760(92)90294-S
StataCorp. Release 13. Statistical software (StataCorp LP, 2013).
RCore, T. R: A Language and Environment for Statistical Computing. http://www.R-project . org (R Foundation for Statistical Computing, 2016).
Maas, C. J. M. & Hox, J. J. Sufficient sample sizes for multilevel modeling. Methodology 1, 86–92 (2005).
doi: 10.1027/1614-2241.1.3.86
Arend, M. G. & Schäfer, T. Statistical power in two-level models: A tutorial based on Monte Carlo simulation. Psychol. methods 24, 1–19 (2019).
pubmed: 30265048
doi: 10.1037/met0000195
Dawson, J. F. & Richter, A. W. Probing three-way interactions in moderated multiple regression: Development and application of a slope difference test. J. Appl. Psychol. 91, 917–926 (2006).
pubmed: 16834514
doi: 10.1037/0021-9010.91.4.917
Bergdahl, J. & Bergdahl, M. Perceived stress in adults: Prevalence and association of depression, anxiety and medication in a Swedish population. Stress Health 18, 235–241 (2002).
doi: 10.1002/smi.946
Forbes, E. E., Williamson, D. E., Ryan, N. D. & Dahl, R. E. Positive and negative affect in depression: Influence of sex and puberty. Ann. N. Y. Acad. Sci. 1021, 341–347 (2004).
pubmed: 15251907
doi: 10.1196/annals.1308.042
Granger, D. A., Hibel, L. C., Fortunato, C. K. & Kapelewski, C. H. Medication effects on salivary cortisol: Tactics and strategy to minimize impact in behavioral and developmental science. Psychoneuroendocrinology 34, 1437–1448 (2009).
pubmed: 19632788
doi: 10.1016/j.psyneuen.2009.06.017
Bauer, D. J., Preacher, K. J. & Gil, K. M. Conceptualizing and testing random indirect effects and moderated mediation in multilevel models: New procedures and recommendations. Psychol. Methods 11, 142–163 (2006).
pubmed: 16784335
doi: 10.1037/1082-989X.11.2.142
Bates, D. et al. Linear mixed-effects models using Eigen and S4. R package version Vol. 1 (2014).
Bolger, N. & Laurenceau, J.-P. Intensive Longitudinal Methods: An Introduction to Diary and Experience Sampling Research (Guilford Press, 2013).