The Pharmacoresistant Epilepsy: An Overview on Existant and New Emerging Therapies.
antiseizure medications (ASMs)
cannabidiol
drug resistant epilepsy
fenfluramine
pharmacoresistance
rational polytherapy
Journal
Frontiers in neurology
ISSN: 1664-2295
Titre abrégé: Front Neurol
Pays: Switzerland
ID NLM: 101546899
Informations de publication
Date de publication:
2021
2021
Historique:
received:
01
03
2021
accepted:
27
05
2021
entrez:
9
7
2021
pubmed:
10
7
2021
medline:
10
7
2021
Statut:
epublish
Résumé
Epilepsy is one of the most common neurological chronic disorders, with an estimated prevalence of 0. 5 - 1%. Currently, treatment options for epilepsy are predominantly based on the administration of symptomatic therapy. Most patients are able to achieve seizure freedom by the first two appropriate drug trials. Thus, patients who cannot reach a satisfactory response after that are defined as pharmacoresistant. However, despite the availability of more than 20 antiseizure medications (ASMs), about one-third of epilepsies remain drug-resistant. The heterogeneity of seizures and epilepsies, the coexistence of comorbidities, and the broad spectrum of efficacy, safety, and tolerability related to the ASMs, make the management of these patients actually challenging. In this review, we analyze the most relevant clinical and pathogenetic issues related to drug-resistant epilepsy, and then we discuss the current evidence about the use of available ASMs and the alternative non-pharmacological approaches.
Identifiants
pubmed: 34239494
doi: 10.3389/fneur.2021.674483
pmc: PMC8258148
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
674483Informations de copyright
Copyright © 2021 Fattorusso, Matricardi, Mencaroni, Dell'Isola, Di Cara, Striano and Verrotti.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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