Nutritional supplementation alters associations between one-carbon metabolites and cardiometabolic risk profiles in older adults: a secondary analysis of the Vienna Active Ageing Study.
Choline
Homocysteine
Nutritional supplement
Older adults
One-carbon metabolism
Journal
European journal of nutrition
ISSN: 1436-6215
Titre abrégé: Eur J Nutr
Pays: Germany
ID NLM: 100888704
Informations de publication
Date de publication:
Feb 2022
Feb 2022
Historique:
received:
05
01
2021
accepted:
02
06
2021
pubmed:
10
7
2021
medline:
27
1
2022
entrez:
9
7
2021
Statut:
ppublish
Résumé
Cardiovascular diseases and cognitive decline, predominant in ageing populations, share common features of dysregulated one-carbon (1C) and cardiometabolic homeostasis. However, few studies have addressed the impact of multifaceted lifestyle interventions in older adults that combine both nutritional supplementation and resistance training on the co-regulation of 1C metabolites and cardiometabolic markers. 95 institutionalised older adults (83 ± 6 years, 88.4% female) were randomised to receive resistance training with or without nutritional supplementation (Fortifit), or cognitive training (control for socialisation) for 6 months. Fasting plasma 1C metabolite concentrations, analysed by liquid chromatography coupled with mass spectrometry, and cardiometabolic parameters were measured at baseline and the 3- and 6-month follow-ups. Regardless of the intervention group, choline was elevated after 3 months, while cysteine and methionine remained elevated after 6 months (mixed model time effects, p < 0.05). Elevated dimethylglycine and lower betaine concentrations were correlated with an unfavourable cardiometabolic profile at baseline (spearman correlations, p < 0.05). However, increasing choline and dimethylglycine concentrations were associated with improvements in lipid metabolism in those receiving supplementation (regression model interaction, p < 0.05). Choline metabolites, including choline, betaine and dimethylglycine, were central to the co-regulation of 1C metabolism and cardiometabolic health in older adults. Metabolites that indicate upregulated betaine-dependent homocysteine remethylation were elevated in those with the greatest cardiometabolic risk at baseline, but associated with improvements in lipid parameters following resistance training with nutritional supplementation. The relevance of how 1C metabolite status might be optimised to protect against cardiometabolic dysregulation requires further attention.
Identifiants
pubmed: 34240265
doi: 10.1007/s00394-021-02607-y
pii: 10.1007/s00394-021-02607-y
pmc: PMC8783863
doi:
Substances chimiques
Homocysteine
0LVT1QZ0BA
Betaine
3SCV180C9W
Carbon
7440-44-0
Choline
N91BDP6H0X
Types de publication
Journal Article
Randomized Controlled Trial
Langues
eng
Sous-ensembles de citation
IM
Pagination
169-182Subventions
Organisme : EU-IRSES
ID : 318962
Organisme : AgResearch (NZ)
ID : A19079
Organisme : AgResearch (NZ)
ID : A21246
Informations de copyright
© 2021. The Author(s).
Références
Br J Nutr. 1999 Mar;81(3):191-201
pubmed: 10434845
Clin Chem. 2016 May;62(5):755-65
pubmed: 26980210
J Biol Chem. 2005 Aug 5;280(31):28299-305
pubmed: 15958390
Nutrients. 2016 Nov 16;8(11):
pubmed: 27854316
Mutagenesis. 2013 Mar;28(2):205-11
pubmed: 23340810
Metabolism. 1993 Nov;42(11):1448-60
pubmed: 7694037
Med Sci Sports Exerc. 2007 Aug;39(8):1401-7
pubmed: 17762374
J Psychiatr Res. 1975 Nov;12(3):189-98
pubmed: 1202204
J Nutr. 2017 Oct;147(10):1968-1976
pubmed: 28855421
Amino Acids. 2015 Apr;47(4):839-46
pubmed: 25577261
Am J Clin Nutr. 2008 May;87(5):1446-54
pubmed: 18469270
JAMA. 2002 Oct 23-30;288(16):2015-22
pubmed: 12387654
Nutrients. 2019 Jun 16;11(6):
pubmed: 31208147
Clin Chem Lab Med. 2007;45(12):1737-45
pubmed: 17963453
Am J Clin Nutr. 2008 Sep;88(3):738-46
pubmed: 18779291
Anal Biochem. 2020 Mar 1;592:113558
pubmed: 31911045
Food Nutr Bull. 2008 Jun;29(2 Suppl):S238-44
pubmed: 18709899
Heart. 2007 Feb;93(2):216-20
pubmed: 16952974
PLoS One. 2014 Nov 17;9(11):e113148
pubmed: 25401978
Cancer Res. 2014 Dec 15;74(24):7442-52
pubmed: 25336191
Clin Chem. 1993 Sep;39(9):1764-79
pubmed: 8375046
Obesity (Silver Spring). 2006 Nov;14(11):1921-30
pubmed: 17135607
J Cardiometab Syndr. 2007 Summer;2(3):183-9
pubmed: 17786082
Curr Opin Clin Nutr Metab Care. 2012 Jan;15(1):49-57
pubmed: 22108094
JAMA Intern Med. 2016 Apr;176(4):473-82
pubmed: 26998708
J Nutr Gerontol Geriatr. 2014;33(1):1-9
pubmed: 24597992
Br J Sports Med. 2009 Jan;43(1):25-7
pubmed: 19019904
Br J Nutr. 2015 Jan;113 Suppl:S18-22
pubmed: 25415221
Eur J Clin Nutr. 2011 Jan;65(1):70-6
pubmed: 20978525
Metabolism. 2006 Aug;55(8):1007-13
pubmed: 16839834
Free Radic Biol Med. 2018 Jun;121:69-77
pubmed: 29698742
Prev Cardiol. 2003 Fall;6(4):197-203
pubmed: 14605513
J Nutr. 2008 May;138(5):914-20
pubmed: 18424601
Circulation. 2012 May 8;125(18):2222-31
pubmed: 22496159
Diabetes. 2016 Apr;65(4):902-12
pubmed: 26858359
Sports Med. 2010 May 1;40(5):397-415
pubmed: 20433212
Circulation. 2007 Aug 28;116(9):1094-105
pubmed: 17671236
Am J Clin Nutr. 1998 Feb;67(2):263-70
pubmed: 9459374
Circulation. 2007 Jul 31;116(5):572-84
pubmed: 17638929
Mutagenesis. 2015 Jan;30(1):147-53
pubmed: 25527737
Sci Rep. 2018 Jan 12;8(1):663
pubmed: 29330539
J Nutr. 2000 Dec;130(12):3090-6
pubmed: 11110875
Exp Gerontol. 2015 Dec;72:99-108
pubmed: 26341720
JAMA. 1993 Dec 8;270(22):2693-8
pubmed: 8133587
Nutr Diabetes. 2012 Oct 08;2:e49
pubmed: 23169489
Am J Clin Nutr. 2017 Jun;105(6):1283-1290
pubmed: 28356272
Diabetes. 2015 Aug;64(8):3010-6
pubmed: 25795213
Br J Nutr. 2012 May;107(10):1408-12
pubmed: 21917195
PLoS One. 2011;6(7):e21666
pubmed: 21747945
Am J Hypertens. 2015 Jul;28(7):943-50
pubmed: 25498997
Clin Chem. 2003 Jan;49(1):113-20
pubmed: 12507967
Annu Rev Nutr. 2016 Jul 17;36:211-39
pubmed: 27431367
J Nutr Health Aging. 2002;6(1):39-42
pubmed: 11813080
Endocr J. 2007 Dec;54(6):995-1002
pubmed: 18079590
Amino Acids. 2014 Aug;46(8):1795-804
pubmed: 24770903
Int J Vitam Nutr Res. 1999 May;69(3):187-93
pubmed: 10389026
Metab Syndr Relat Disord. 2006 Fall;4(3):185-95
pubmed: 18370737
Kidney Int. 1997 Jul;52(1):10-20
pubmed: 9211341
Exp Gerontol. 2015 May;65:16-22
pubmed: 25747997
Scand J Clin Lab Invest. 1996 Feb;56(1):41-6
pubmed: 8850171
Scand J Clin Lab Invest. 2018 Nov - Dec;78(7-8):527-532
pubmed: 30261756