Mechanical Frustration of Phase Separation in the Cell Nucleus by Chromatin.
Journal
Physical review letters
ISSN: 1079-7114
Titre abrégé: Phys Rev Lett
Pays: United States
ID NLM: 0401141
Informations de publication
Date de publication:
25 Jun 2021
25 Jun 2021
Historique:
received:
24
12
2020
accepted:
18
05
2021
entrez:
9
7
2021
pubmed:
10
7
2021
medline:
22
7
2021
Statut:
ppublish
Résumé
Liquid-liquid phase separation is a fundamental mechanism underlying subcellular organization. Motivated by the striking observation that optogenetically generated droplets in the nucleus display suppressed coarsening dynamics, we study the impact of chromatin mechanics on droplet phase separation. We combine theory and simulation to show that cross-linked chromatin can mechanically suppress droplets' coalescence and ripening, as well as quantitatively control their number, size, and placement. Our results highlight the role of the subcellular mechanical environment on condensate regulation.
Identifiants
pubmed: 34241518
doi: 10.1103/PhysRevLett.126.258102
pmc: PMC8604804
mid: NIHMS1756992
doi:
Substances chimiques
Chromatin
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
258102Subventions
Organisme : NIGMS NIH HHS
ID : R01 GM082938
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM140032
Pays : United States
Organisme : NHGRI NIH HHS
ID : T32 HG003284
Pays : United States
Organisme : NIDA NIH HHS
ID : U01 DA040601
Pays : United States
Commentaires et corrections
Type : ErratumIn
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