Immunological lessons from CD28 deficiency in humans.

Alphapapillomavirus CD28 Antigens / genetics Cytomegalovirus / genetics Epstein-Barr Virus Infections Herpesvirus 4, Human / genetics Humans

Journal

Cell
ISSN: 1097-4172
Titre abrégé: Cell
Pays: United States
ID NLM: 0413066

Informations de publication

Date de publication:
08 07 2021
Historique:
entrez: 9 7 2021
pubmed: 10 7 2021
medline: 24 12 2021
Statut: ppublish

Résumé

In this issue of Cell, Casanova and colleagues examine three family members with a mutation that results in deficiency of the T cell co-stimulatory molecule CD28. These patients exhibit clinical symptoms due to human papillomavirus-2 and -4 infections, show increased levels of Epstein-Barr virus and cytomegalovirus in the blood, and respond poorly to vaccines.

Identifiants

DOI: 10.1016/j.cell.2021.06.014 PMID: 34242561
pubmed: 34242561
pii: S0092-8674(21)00749-2
doi: 10.1016/j.cell.2021.06.014
pii:
doi:

Substances chimiques

CD28 Antigens 0

Types de publication

Journal Article Comment

Langues

eng

Sous-ensembles de citation

IM

Pagination

3595-3597

Commentaires et corrections

Type : CommentOn

Informations de copyright

Copyright © 2021 Elsevier Inc. All rights reserved.

Auteurs

Andreas Wieland (A)

Emory Vaccine Center, Emory University School of Medicine, Atlanta, GA, USA; Department of Microbiology & Immunology, Emory University School of Medicine, Atlanta, GA, USA.

Rafi Ahmed (R)

Emory Vaccine Center, Emory University School of Medicine, Atlanta, GA, USA; Department of Microbiology & Immunology, Emory University School of Medicine, Atlanta, GA, USA. Electronic address: rahmed@emory.edu.

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Classifications MeSH

questionsmedicales.fr › Virus › Virus oncogènes › Virus tumoraux à ADN › Papillomaviridae › Alphapapillomavirus › Immunological lessons from CD28 deficiency in humans.
questionsmedicales.fr › Facteurs biologiques › Marqueurs biologiques › Antigènes de différenciation › Antigènes de différenciation des lymphocytes T › Antigène CD28 › Immunological lessons from CD28 deficiency in humans.
questionsmedicales.fr › Virus › Virus à ADN › Herpesviridae › Betaherpesvirinae › Cytomegalovirus › Immunological lessons from CD28 deficiency in humans.
questionsmedicales.fr › Infection › Maladies virales › Infections à virus oncogènes › Infections à virus Epstein-Barr › Immunological lessons from CD28 deficiency in humans.
questionsmedicales.fr › Virus › Virus oncogènes › Virus tumoraux à ADN › Gammaherpesvirinae › Lymphocryptovirus › Herpèsvirus humain de type 4 › Immunological lessons from CD28 deficiency in humans.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Immunological lessons from CD28 deficiency in humans.