Consequences of the different order of immunoglobulin gene rearrangements in swine.
B cell development
B cell receptors
Cell differentiation
Immunoglobulin rearrangement
Other animals
Porcine immune system
Journal
Developmental and comparative immunology
ISSN: 1879-0089
Titre abrégé: Dev Comp Immunol
Pays: United States
ID NLM: 7708205
Informations de publication
Date de publication:
01 2022
01 2022
Historique:
received:
23
04
2021
revised:
14
06
2021
accepted:
30
06
2021
pubmed:
10
7
2021
medline:
8
4
2022
entrez:
9
7
2021
Statut:
ppublish
Résumé
Swine use a reverse order of immunoglobulin chain rearrangement compared to humans and mice, and this altered and modified order should have measurable consequences. Here we perform new and defining experiments with developing and mature B cells, characterizing the B cell populations that do not exist in other species. First, we have finally confirmed that light chains κ and λ are rearranged and expressed on the surface before any heavy chain rearrangements using western-blot. And second, we have analyzed a pool of mature B cells on the single-cell level to demonstrate that many κ
Identifiants
pubmed: 34242678
pii: S0145-305X(21)00204-4
doi: 10.1016/j.dci.2021.104196
pii:
doi:
Substances chimiques
Immunoglobulin Light Chains
0
Immunoglobulin kappa-Chains
0
Immunoglobulin lambda-Chains
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
104196Informations de copyright
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