bioimpedance
cardiac fibroblast
cardiac fibrosis
in vitro assay
myofibroblast
xCELLigence technique
Journal
Biomedical physics & engineering express
ISSN: 2057-1976
Titre abrégé: Biomed Phys Eng Express
Pays: England
ID NLM: 101675002
Informations de publication
Date de publication:
07 07 2022
07 07 2022
Historique:
received:
21
04
2021
accepted:
09
07
2021
pubmed:
10
7
2021
medline:
9
7
2022
entrez:
9
7
2021
Statut:
epublish
Résumé
Cardiac arrhythmias represent about 50% of the cardiovascular diseases which are the first cause of mortality in the world. Implantable medical devices play a major role for treating these arrhythmias. Nevertheless the leads induce an unwanted biological phenomenon called fibrosis. This phenomenon begins at a cellular level and is effective at a macroscopic scale causing tissue remodelling with a local modification of the active cardiac tissue. Fibrosis mechanism is complex but at the cellular level, it mainly consists in cardiac fibroblasts activation and differentiation into myofibroblasts. We developed a simplified
Identifiants
pubmed: 34243179
doi: 10.1088/2057-1976/ac12e1
doi:
Substances chimiques
Transforming Growth Factor beta1
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
© 2022 IOP Publishing Ltd.