High-power near-concentric Fabry-Perot cavity for phase contrast electron microscopy.
Journal
The Review of scientific instruments
ISSN: 1089-7623
Titre abrégé: Rev Sci Instrum
Pays: United States
ID NLM: 0405571
Informations de publication
Date de publication:
01 May 2021
01 May 2021
Historique:
entrez:
10
7
2021
pubmed:
11
7
2021
medline:
11
7
2021
Statut:
ppublish
Résumé
Transmission electron microscopy (TEM) of vitrified biological macromolecules (cryo-EM) is limited by the weak phase contrast signal that is available from such samples. Using a phase plate would thus substantially improve the signal-to-noise ratio. We have previously demonstrated the use of a high-power Fabry-Perot cavity as a phase plate for TEM. We now report improvements to our laser cavity that allow us to achieve record continuous wave intensities of over 450 GW/cm
Identifiants
pubmed: 34243315
doi: 10.1063/5.0045496
pmc: PMC8159438
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
053005Subventions
Organisme : NIGMS NIH HHS
ID : R01 GM126011
Pays : United States
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