Infantile neuroblastoma and maternal occupational exposure to medical agents.
Journal
Pediatric research
ISSN: 1530-0447
Titre abrégé: Pediatr Res
Pays: United States
ID NLM: 0100714
Informations de publication
Date de publication:
09 Jul 2021
09 Jul 2021
Historique:
received:
16
01
2021
accepted:
11
05
2021
revised:
07
04
2021
entrez:
10
7
2021
pubmed:
11
7
2021
medline:
11
7
2021
Statut:
aheadofprint
Résumé
Healthcare workers are often exposed to hazardous agents and are at risk for adverse health consequences that affect not only themselves but also their infants. This study aimed to examine whether such occupational exposure increased the risk of childhood cancer in offspring. We used the dataset of the Japan Environment and Children's Study, a nationwide birth cohort involving over 100,000 mother-child pairs. Information was obtained via successive questionnaires that were completed until the child turned 1 year of age. The parents were asked whether they occupationally handled medical agents during pregnancy. A total of 26 infants developed neoplasms: neuroblastoma, leukemia, and brain tumor. The incidence of neuroblastoma was significantly higher in infants whose mothers were exposed to radiation (3/2142: 140.1 per 100,000 population) than in those who were not (12/90,384: 13.3 per 100,000 population). Multivariable regression analyses revealed a close association between maternal irradiation and the development of neuroblastoma (adjusted incident rate ratio: 10.68 [95% confidence interval: 2.98‒38.27]). The present study demonstrated, for the first time, a potential association between maternal occupational exposure and the occurrence of neuroblastoma in offspring. Further studies involving the large pediatric cancer registries are needed to confirm these preliminary results. Healthcare workers are often exposed to hazardous agents and are at risk for adverse health consequences that affect not only themselves but also their infants. This study examined the association between such occupational exposure and offspring's cancers that developed until the age of 1 year. Maternal exposure to ionizing radiation was associated with infantile neuroblastoma in offspring. Further studies involving the large pediatric cancer registries are needed to confirm these preliminary results.
Sections du résumé
BACKGROUND
BACKGROUND
Healthcare workers are often exposed to hazardous agents and are at risk for adverse health consequences that affect not only themselves but also their infants. This study aimed to examine whether such occupational exposure increased the risk of childhood cancer in offspring.
METHODS
METHODS
We used the dataset of the Japan Environment and Children's Study, a nationwide birth cohort involving over 100,000 mother-child pairs. Information was obtained via successive questionnaires that were completed until the child turned 1 year of age. The parents were asked whether they occupationally handled medical agents during pregnancy.
RESULTS
RESULTS
A total of 26 infants developed neoplasms: neuroblastoma, leukemia, and brain tumor. The incidence of neuroblastoma was significantly higher in infants whose mothers were exposed to radiation (3/2142: 140.1 per 100,000 population) than in those who were not (12/90,384: 13.3 per 100,000 population). Multivariable regression analyses revealed a close association between maternal irradiation and the development of neuroblastoma (adjusted incident rate ratio: 10.68 [95% confidence interval: 2.98‒38.27]).
CONCLUSIONS
CONCLUSIONS
The present study demonstrated, for the first time, a potential association between maternal occupational exposure and the occurrence of neuroblastoma in offspring. Further studies involving the large pediatric cancer registries are needed to confirm these preliminary results.
IMPACT
CONCLUSIONS
Healthcare workers are often exposed to hazardous agents and are at risk for adverse health consequences that affect not only themselves but also their infants. This study examined the association between such occupational exposure and offspring's cancers that developed until the age of 1 year. Maternal exposure to ionizing radiation was associated with infantile neuroblastoma in offspring. Further studies involving the large pediatric cancer registries are needed to confirm these preliminary results.
Identifiants
pubmed: 34244617
doi: 10.1038/s41390-021-01634-z
pii: 10.1038/s41390-021-01634-z
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Investigateurs
Michihiro Kamijima
(M)
Shin Yamazaki
(S)
Yukihiro Ohya
(Y)
Reiko Kishi
(R)
Nobuo Yaegashi
(N)
Koichi Hashimoto
(K)
Chisato Mori
(C)
Shuichi Ito
(S)
Zentaro Yamagata
(Z)
Hidekuni Inadera
(H)
Takeo Nakayama
(T)
Hiroyasu Iso
(H)
Masayuki Shima
(M)
Youichi Kurozawa
(Y)
Narufumi Suganuma
(N)
Koichi Kusuhara
(K)
Takahiko Katoh
(T)
Informations de copyright
© 2021. The Author(s).
Références
Fucic, A., Guszak, V. & Mantovani, A. Transplacental exposure to environmental carcinogens: association with childhood cancer risks and the role of modulating factors. Reprod. Toxicol. 72, 182–190 (2017).
pubmed: 28624605
doi: 10.1016/j.reprotox.2017.06.044
Colt, J. S. & Blair, A. Parental occupational exposures and risk of childhood cancer. Environ. Health Perspect. 106(Suppl. 3), 909–925 (1998).
pubmed: 9646055
pmcid: 1533069
International Consortium for Research on the Health Effects of Radiation, Writing Committee and Study Team. Childhood leukaemia in Belarus, Russia, and Ukraine following the Chernobyl power station accident: results from an international collaborative population-based case-control study. Int. J. Epidemiol. 35, 386–396 (2006).
doi: 10.1093/ije/dyi220
Skov, T. et al. Leukaemia and reproductive outcome among nurses handling antineoplastic drugs. Br. J. Ind. Med. 49, 855–861 (1992).
pubmed: 1472444
pmcid: 1061216
International Agency for Research on Cancer. International Incidence of Childhood Cancer, volume III (electronic version). https://iicc.iarc.fr/includes/results/registries/Asia/Asia_JAPAN_8-registries.pdf (2021).
Bross, I. D. & Natarajan, N. Risk of leukemia in susceptible children exposed to preconception, in utero and postnatal radiation. Prev. Med. 3, 361–369 (1974).
pubmed: 4415641
doi: 10.1016/0091-7435(74)90048-6
pmcid: 4415641
Schwartzbaum, J. A. Influence of the mother’s prenatal drug consumption on risk of neuroblastoma in the child. Am. J. Epidemiol. 135, 1358–1367 (1992).
pubmed: 1510082
doi: 10.1093/oxfordjournals.aje.a116247
pmcid: 1510082
Patton, T., Olshan, A. F., Neglia, J. P., Castleberry, R. P. & Smith, J. Parental exposure to medical radiation and neuroblastoma in offspring. Paediatr. Perinat. Epidemiol. 18, 178–185 (2004).
pubmed: 15130156
doi: 10.1111/j.1365-3016.2004.00554.x
pmcid: 15130156
Schulze-Rath, R., Hammer, G. P. & Blettner, M. Are pre- or postnatal diagnostic X-rays a risk factor for childhood cancer? A systematic review. Radiat. Environ. Biophys. 47, 301–312 (2008).
pubmed: 18528700
doi: 10.1007/s00411-008-0171-2
pmcid: 18528700
Rajaraman, P. et al. Early life exposure to diagnostic radiation and ultrasound scans and risk of childhood cancer: case-control study. BMJ 342, d472 (2011).
pubmed: 21310791
pmcid: 3037470
doi: 10.1136/bmj.d472
Kawamoto, T. et al. Rationale and study design of the Japan environment and children’s study (JECS). BMC Public Health 14, 25 (2014).
pubmed: 24410977
pmcid: 3893509
doi: 10.1186/1471-2458-14-25
Michikawa, T. et al. Baseline profile of participants in the Japan Environment and Children’s Study (JECS). J. Epidemiol. 28, 99–104 (2018).
pubmed: 29093304
pmcid: 5792233
doi: 10.2188/jea.JE20170018
Iwai-Shimada, M. et al. Questionnaire results on exposure characteristics of pregnant women participating in the Japan Environment and Children Study (JECS). Environ. Health Prev. Med. 23, 45 (2018).
pubmed: 30219031
pmcid: 6138908
doi: 10.1186/s12199-018-0733-0
Heck, J. E., Ritz, B., Hung, R. J., Hashibe, M. & Boffetta, P. The epidemiology of neuroblastoma: a review. Paediatr. Perinat. Epidemiol. 23, 125–143 (2009).
pubmed: 19159399
doi: 10.1111/j.1365-3016.2008.00983.x
Spitz, M. R. & Johnson, C. C. Neuroblastoma and paternal occupation. A case-control analysis. Am. J. Epidemiol. 121, 924–929 (1985).
pubmed: 4014183
doi: 10.1093/oxfordjournals.aje.a114062
Bunin, G. R., Ward, E., Kramer, S., Rhee, C. A. & Meadows, A. T. Neuroblastoma and parental occupation. Am. J. Epidemiol. 131, 776–780 (1990).
pubmed: 2321622
doi: 10.1093/oxfordjournals.aje.a115568
Wilkins, J. R. 3rd & Hundley, V. D. Paternal occupational exposure to electromagnetic fields and neuroblastoma in offspring. Am. J. Epidemiol. 131, 995–1008 (1990).
pubmed: 2343871
doi: 10.1093/oxfordjournals.aje.a115620
Schuz, J. et al. Risk factors for neuroblastoma at different stages of disease. Results from a population-based case-control study in Germany. J. Clin. Epidemiol. 54, 702–709 (2001).
pubmed: 11438411
doi: 10.1016/S0895-4356(00)00339-5
Kerr, M. A. et al. Parental occupational exposures and risk of neuroblastoma: a case-control study (United States). Cancer Causes Control 11, 635–643 (2000).
pubmed: 10977108
doi: 10.1023/A:1008951632482
De Roos, A. J. et al. Parental occupational exposures to chemicals and incidence of neuroblastoma in offspring. Am. J. Epidemiol. 154, 106–114 (2001).
pubmed: 11447042
doi: 10.1093/aje/154.2.106
pmcid: 11447042
Pearce, M. S., Hammal, D. M., Dorak, M. T., McNally, R. J. & Parker, L. Paternal occupational exposure to pesticides or herbicides as risk factors for cancer in children and young adults: a case-control study from the North of England. Arch. Environ. Occup. Health 61, 138–144 (2006).
pubmed: 17672356
doi: 10.3200/AEOH.61.3.138-144
pmcid: 17672356
Su, L. et al. Association between parental occupational exposure to extremely low frequency magnetic fields and childhood nervous system tumors risk: a meta-analysis. Sci. Total Environ. 642, 1406–1414 (2018).
pubmed: 30045521
doi: 10.1016/j.scitotenv.2018.06.142
pmcid: 30045521
De Roos, A. J. et al. Parental occupational exposures to electromagnetic fields and radiation and the incidence of neuroblastoma in offspring. Epidemiology 12, 508–517 (2001).
pubmed: 11505168
doi: 10.1097/00001648-200109000-00008
pmcid: 11505168
Wakeford, R. The risk of childhood cancer from intrauterine and preconceptional exposure to ionizing radiation. Environ. Health Perspect. 103, 1018–1025 (1995).
pubmed: 8605850
pmcid: 1519200
doi: 10.1289/ehp.951031018
Gardner, M. J. et al. Results of case-control study of leukaemia and lymphoma among young people near Sellafield nuclear plant in West Cumbria. BMJ 300, 423–429 (1990).
pubmed: 2107892
pmcid: 1662259
doi: 10.1136/bmj.300.6722.423
Draper, G. J. et al. Cancer in the offspring of radiation workers: a record linkage study. BMJ 315, 1181–1188 (1997).
pubmed: 9393219
pmcid: 2127770
doi: 10.1136/bmj.315.7117.1181
Sorahan, T. et al. Cancer in the offspring of radiation workers: an investigation of employment timing and a reanalysis using updated dose information. Br. J. Cancer 89, 1215–1220 (2003).
pubmed: 14520449
pmcid: 2394296
doi: 10.1038/sj.bjc.6601273
Roman, E. et al. Cancer in children of nuclear industry employees: report on children aged under 25 years from nuclear industry family study. BMJ 318, 1443–1450 (1999).
pubmed: 10346768
pmcid: 27886
doi: 10.1136/bmj.318.7196.1443
Meinert, R., Kaletsch, U., Kaatsch, P., Schuz, J. & Michaelis, J. Associations between childhood cancer and ionizing radiation: results of a population-based case-control study in Germany. Cancer Epidemiol. Biomark. Prev. 8, 793–799 (1999).
Bunch, K. J. et al. Cancer in the offspring of female radiation workers: a record linkage study. Br. J. Cancer 100, 213–218 (2009).
pubmed: 19127273
pmcid: 2634667
doi: 10.1038/sj.bjc.6604841
Sever, L. E., Gilbert, E. S., Tucker, K., Greaves, J. A. & Buchanan, J. Epidemiological Evaluation of Childhood Leukaemia and Paternal Exposure to Ionizing Raditaion. Final report. Centers for Disease Control, Cooperative Agreement U50/CCU012545-01 (National Institute for Occupational Safety and Health, 1997).
McLaughlin, J. R., King, W. D., Anderson, T. W., Clarke, E. A. & Ashmore, J. P. Paternal radiation exposure and leukaemia in offspring: the Ontario case-control study. BMJ 307, 959–966 (1993).
pubmed: 8241906
pmcid: 1679166
doi: 10.1136/bmj.307.6910.959
Yoshimoto, Y. et al. Malignant tumors during the first 2 decades of life in the offspring of atomic bomb survivors. Am. J. Hum. Genet. 46, 1041–1052 (1990).
pubmed: 2160192
pmcid: 1683841
Draper, G. Preconception exposures to potential germ-cell mutagens. Radiat. Prot. Dosim. 132, 241–245 (2008).
doi: 10.1093/rpd/ncn256
Giles, D., Hewitt, D., Stewart, A. & Webb, J. Malignant disease in childhood and diagnostic irradiation in utero. Lancet 271, 447 (1956).
pubmed: 13358242
Macmahon, B. Prenatal x-ray exposure and childhood cancer. J. Natl Cancer Inst. 28, 1173–1191 (1962).
pubmed: 14468031
Mole, R. H. Childhood cancer after prenatal exposure to diagnostic X-ray examinations in Britain. Br. J. Cancer 62, 152–168 (1990).
pubmed: 2202420
pmcid: 1971756
doi: 10.1038/bjc.1990.249
Doll, R. & Wakeford, R. Risk of childhood cancer from fetal irradiation. Br. J. Radiol. 70, 130–139 (1997).
pubmed: 9135438
doi: 10.1259/bjr.70.830.9135438
Hon, C. Y., Teschke, K., Demers, P. A. & Venners, S. Antineoplastic drug contamination on the hands of employees working throughout the hospital medication system. Ann. Occup. Hyg. 58, 761–770 (2014).
pubmed: 24644303
Fransman, W. et al. A pooled analysis to study trends in exposure to antineoplastic drugs among nurses. Ann. Occup. Hyg. 51, 231–239 (2007).
pubmed: 17337460
pmcid: 17337460
Kiffmeyer, T. K. et al. Vapour pressures, evaporation behaviour and airborne concentrations of hazardous drugs: implications for occupational safety. Pharm. J. 268, 331–337 (2002).
Falck, K. et al. Mutagenicity in urine of nurses handling cytostatic drugs. Lancet 1, 1250–1251 (1979).
pubmed: 87722
doi: 10.1016/S0140-6736(79)91939-1
pmcid: 87722
Connor, T. H., Lawson, C. C., Polovich, M. & McDiarmid, M. A. Reproductive health risks associated with occupational exposures to antineoplastic drugs in health care settings: a review of the evidence. J. Occup. Environ. Med. 56, 901–910 (2014).
pubmed: 25153300
pmcid: 4569003
doi: 10.1097/JOM.0000000000000249
Lawson, C. C. et al. Occupational exposures among nurses and risk of spontaneous abortion. Am. J. Obstet. Gynecol. 206, 327 e1–327 e8 (2012).
doi: 10.1016/j.ajog.2011.12.030
Connor, T. H. & McDiarmid, M. A. Preventing occupational exposures to antineoplastic drugs in health care settings. CA Cancer J. Clin. 56, 354–365 (2006).
pubmed: 17135692
doi: 10.3322/canjclin.56.6.354
pmcid: 17135692
Roussel, C., Witt, K. L., Shaw, P. B. & Connor, T. H. Meta-analysis of chromosomal aberrations as a biomarker of exposure in healthcare workers occupationally exposed to antineoplastic drugs. Mutat. Res. 781, 207–217 (2019).
pubmed: 31416576
doi: 10.1016/j.mrrev.2017.08.002
pmcid: 31416576