Acute thalamic damage as a prognostic biomarker for post-traumatic epileptogenesis.
EEG
MRI
epilepsy
traumatic brain injury
Journal
Epilepsia
ISSN: 1528-1167
Titre abrégé: Epilepsia
Pays: United States
ID NLM: 2983306R
Informations de publication
Date de publication:
08 2021
08 2021
Historique:
revised:
17
06
2021
received:
16
04
2021
accepted:
17
06
2021
pubmed:
11
7
2021
medline:
5
1
2022
entrez:
10
7
2021
Statut:
ppublish
Résumé
To identify magnetic resonance imaging (MRI) biomarkers for post-traumatic epilepsy. The EPITARGET (Targets and biomarkers for antiepileptogenesis, epitarget.eu) animal cohort completing T Twenty-nine percent (28/98) of the rats with traumatic brain injury (TBI) developed epilepsy. The best-performing logistic regression model utilized the D2 and D7 T An MRI parameter set reporting on acute and subacute neuropathologic changes common to experimental and human TBI presents a diagnostic biomarker for post-traumatic epileptogenesis. Significant enrichment of the study population was achieved even when using a single time-point measurement, producing an expected epilepsy rate of 73%.
Substances chimiques
Biomarkers
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1852-1864Informations de copyright
© 2021 The Authors. Epilepsia published by Wiley Periodicals LLC on behalf of International League Against Epilepsy.
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