Delineating papillary dermis around basal cell carcinomas by high and ultrahigh resolution optical coherence tomography-A pilot study.

BCC OCT angiography basal cell carcinoma optical coherence tomography papillary dermis ultrahigh resolution upper dermis

Journal

Journal of biophotonics
ISSN: 1864-0648
Titre abrégé: J Biophotonics
Pays: Germany
ID NLM: 101318567

Informations de publication

Date de publication:
11 2021
Historique:
revised: 18 06 2021
received: 11 03 2021
accepted: 08 07 2021
pubmed: 11 7 2021
medline: 15 12 2021
entrez: 10 7 2021
Statut: ppublish

Résumé

Bedside diagnosis of skin cancer remains a challenging task. The real-time noninvasive technology of optical coherence tomography (OCT) masters a high diagnostic accuracy in basal cell carcinoma (BCC) but a lower specificity in recognizing imitators and other carcinomas. We investigate the delicate signal of papillary dermis using an in-house developed ultrahigh resolution OCT (UHR-OCT) system with shadow compensation and a commercial multi-focus high resolution OCT (HR-OCT) system for clinical BCC imaging. We find that the HR-OCT system struggled to resolve the dark band signal of papillary dermis where the UHR-OCT located this in all cases and detected changes in signal width. UHR-OCT is able to monitor extension and position of papillary dermis suggesting a novel feature for delineating superficial BCCs in pursuit of a fast accurate diagnosis. Comprehensive studies involving more patients are imperative in order to corroborate results.

Identifiants

pubmed: 34245133
doi: 10.1002/jbio.202100083
doi:

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

e202100083

Informations de copyright

© 2021 Wiley-VCH GmbH.

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Auteurs

Niels Møller Israelsen (N)

DTU Fotonik, Department of Photonics Engineering, Technical University of Denmark, Kongens Lyngby, Denmark.

Mette Mogensen (M)

Department of Dermatology, Bisbebjerg Hospital, University Hospitals of Copenhagen, Copenhagen, NV, Denmark.

Mikkel Jensen (M)

DTU Fotonik, Department of Photonics Engineering, Technical University of Denmark, Kongens Lyngby, Denmark.

Merete Haedersdal (M)

Department of Dermatology, Bisbebjerg Hospital, University Hospitals of Copenhagen, Copenhagen, NV, Denmark.

Ole Bang (O)

DTU Fotonik, Department of Photonics Engineering, Technical University of Denmark, Kongens Lyngby, Denmark.
NKT Photonics A/S, Birkerød, Denmark.

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