TSPO imaging in animal models of brain diseases.
Alzheimer’s disease
Multiple sclerosis
Neuroinflammation
Parkinson’s disease
Positron emission tomography
Stroke
Translocator protein 18 kDa
Journal
European journal of nuclear medicine and molecular imaging
ISSN: 1619-7089
Titre abrégé: Eur J Nucl Med Mol Imaging
Pays: Germany
ID NLM: 101140988
Informations de publication
Date de publication:
12 2021
12 2021
Historique:
received:
01
03
2021
accepted:
25
04
2021
pubmed:
11
7
2021
medline:
3
2
2022
entrez:
10
7
2021
Statut:
ppublish
Résumé
Over the last 30 years, the 18-kDa TSPO protein has been considered as the PET imaging biomarker of reference to measure increased neuroinflammation. Generally assumed to image activated microglia, TSPO has also been detected in endothelial cells and activated astrocytes. Here, we provide an exhaustive overview of the recent literature on the TSPO-PET imaging (i) in the search and development of new TSPO tracers and (ii) in the understanding of acute and chronic neuroinflammation in animal models of neurological disorders. Generally, studies testing new TSPO radiotracers against the prototypic [
Identifiants
pubmed: 34245328
doi: 10.1007/s00259-021-05379-z
pii: 10.1007/s00259-021-05379-z
pmc: PMC8712305
doi:
Substances chimiques
Radiopharmaceuticals
0
Receptors, GABA
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
77-109Subventions
Organisme : NCATS NIH HHS
ID : UL1 TR001863
Pays : United States
Informations de copyright
© 2021. The Author(s).
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