Reproductive aging and telomeres: Are women and men equally affected?
Aging
Oocyte
Reproduction
Sperm
Telomeres
Journal
Mechanisms of ageing and development
ISSN: 1872-6216
Titre abrégé: Mech Ageing Dev
Pays: Ireland
ID NLM: 0347227
Informations de publication
Date de publication:
09 2021
09 2021
Historique:
received:
31
03
2021
revised:
01
07
2021
accepted:
05
07
2021
pubmed:
11
7
2021
medline:
19
2
2022
entrez:
10
7
2021
Statut:
ppublish
Résumé
Successful reproduction is very important for individuals and for society. Currently, the human health span and lifespan are the object of intense and productive investigation with great achievements, compared to the last century. However, reproduction span does not progress concomitantly with lifespan. Reproductive organs age, decreasing the levels of sexual hormones, which are protectors of health through their action on several organs of the body. Thus, this is the starting point of the organismal decay and infertility. This starting point is easily detected in women. In men, it goes under the surface, undetected, but it goes, nevertheless. Regarding fertility, aging alters the hormonal equilibrium, decreases the potential of reproductive organs, diminishes the quality of the gametes and worsen the reproductive outcomes. All these events happen at a different pace and affecting different organs in women and men. The question is what molecular pathways are involved in reproductive aging and if there is a possible halting or even reversion of the aging events. Answers to all these points will be explained in the present review.
Identifiants
pubmed: 34245740
pii: S0047-6374(21)00113-5
doi: 10.1016/j.mad.2021.111541
pii:
doi:
Substances chimiques
Gonadal Steroid Hormones
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
111541Informations de copyright
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