Predictors of social functioning and quality of life in schizophrenia and autism spectrum disorder.
IQ
Negative symptoms
Social cognition
Journal
Psychiatry research
ISSN: 1872-7123
Titre abrégé: Psychiatry Res
Pays: Ireland
ID NLM: 7911385
Informations de publication
Date de publication:
09 2021
09 2021
Historique:
received:
06
01
2021
revised:
18
06
2021
accepted:
26
06
2021
pubmed:
11
7
2021
medline:
28
10
2021
entrez:
10
7
2021
Statut:
ppublish
Résumé
Schizophrenia (SZ) and Autism Spectrum Disorder (ASD) show overlap in social cognitive and functioning impairments. Proposed predictors of social functioning (SF) and quality of life (QL) have been symptom severity, IQ and social cognition. Empathy has rarely been compared between ASD and SZ and its predictive power on functional outcomes is unclear. We investigated general, affective, and cognitive empathy in 46 SZ, 30 ASD and 51 healthy controls (HC) and examined their relationship to SF and QL in addition to IQ and symptoms. SZ and ASD shared deficits in general and cognitive empathy, and personal distress, but only SZ showed deficits in affective empathy. Both groups showed lower performance-based empathy scores and only ASD showed slower responses compared to HC. Negative symptoms predicted QL in both groups, the more negative symptoms the worse QL (ASD t=-3.22; SZ t= -3.43; p<0.01), and only in ASD, IQ predicted QL, the higher the IQ the higher QL (t = 2.1; p<0.05). In ASD only, negative symptoms predicted SF, the greater negative symptoms the worse SF (t=-3.45; p<0.01), and communication deficits predicted SF, the higher deficits, the higher SF (t = 2.9; p<0.01). Negative symptoms but not empathy were the shared predictors of functioning across ASD and SZ.
Identifiants
pubmed: 34246005
pii: S0165-1781(21)00384-X
doi: 10.1016/j.psychres.2021.114087
pmc: PMC8373814
mid: NIHMS1722497
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
114087Subventions
Organisme : RRD VA
ID : IK6 RX002458
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH095888
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR001863
Pays : United States
Informations de copyright
Copyright © 2021 Elsevier B.V. All rights reserved.
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