Impulsivity in cocaine users compared to matched controls: Effects of sex and preferred route of cocaine use.
Cocaine
Delay discounting
Impulsivity
Preferred route
Sensation-seeking
Sex differences
Journal
Drug and alcohol dependence
ISSN: 1879-0046
Titre abrégé: Drug Alcohol Depend
Pays: Ireland
ID NLM: 7513587
Informations de publication
Date de publication:
01 09 2021
01 09 2021
Historique:
received:
24
02
2021
revised:
26
04
2021
accepted:
01
05
2021
pubmed:
12
7
2021
medline:
29
9
2021
entrez:
11
7
2021
Statut:
ppublish
Résumé
Impulsivity has been identified as playing a role in cocaine use. The purpose of this study was to explore self-report measures of impulsivity in large groups of male and female cocaine users and matched controls and to determine if differences in impulsivity measures within a group of cocaine users related to self-reported money spent on cocaine and route of cocaine use. Eight self-report impulsivity measures yielding 34 subscales were obtained in 230 cocaine users (180 M, 50 F) and a matched group of 119 healthy controls (89 M, 30 F). Correlational analysis of the questionnaires revealed 2 factors: Impulsive Action (Factor 1) consisting of many traditional impulsivity measures and Thrill-seeking (Factor 2) consisting of delay discounting, sensation and thrill seeking. Sex influenced within group comparisons. Impulsive Action scores did not vary as a function of sex within either group. But, male controls and male cocaine users had greater Thrill-seeking scores than females within the same group. Sex also influenced between group comparisons. Male cocaine users had greater Impulsive Action scores while female cocaine users had greater Thrill-seeking scores than their sex-matched controls. Among cocaine users, individuals who preferred insufflating ("snorting") cocaine had greater Thrill-seeking scores and lower Impulsive Action scores than individuals who preferred smoking cocaine. Individuals who insufflate cocaine also spent less money on cocaine. Greater Impulsive Action scores in males and Thrill-seeking scores in females were associated with cocaine use relative to controls.
Sections du résumé
BACKGROUND
Impulsivity has been identified as playing a role in cocaine use. The purpose of this study was to explore self-report measures of impulsivity in large groups of male and female cocaine users and matched controls and to determine if differences in impulsivity measures within a group of cocaine users related to self-reported money spent on cocaine and route of cocaine use.
METHODS
Eight self-report impulsivity measures yielding 34 subscales were obtained in 230 cocaine users (180 M, 50 F) and a matched group of 119 healthy controls (89 M, 30 F). Correlational analysis of the questionnaires revealed 2 factors: Impulsive Action (Factor 1) consisting of many traditional impulsivity measures and Thrill-seeking (Factor 2) consisting of delay discounting, sensation and thrill seeking.
RESULTS
Sex influenced within group comparisons. Impulsive Action scores did not vary as a function of sex within either group. But, male controls and male cocaine users had greater Thrill-seeking scores than females within the same group. Sex also influenced between group comparisons. Male cocaine users had greater Impulsive Action scores while female cocaine users had greater Thrill-seeking scores than their sex-matched controls. Among cocaine users, individuals who preferred insufflating ("snorting") cocaine had greater Thrill-seeking scores and lower Impulsive Action scores than individuals who preferred smoking cocaine. Individuals who insufflate cocaine also spent less money on cocaine.
CONCLUSIONS
Greater Impulsive Action scores in males and Thrill-seeking scores in females were associated with cocaine use relative to controls.
Identifiants
pubmed: 34246916
pii: S0376-8716(21)00335-5
doi: 10.1016/j.drugalcdep.2021.108840
pmc: PMC8355072
mid: NIHMS1720924
pii:
doi:
Substances chimiques
Cocaine
I5Y540LHVR
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
108840Subventions
Organisme : NIDA NIH HHS
ID : R01 DA035846
Pays : United States
Organisme : NIDA NIH HHS
ID : T32 DA007294
Pays : United States
Informations de copyright
Copyright © 2021 Elsevier B.V. All rights reserved.
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