Cognitive Profiles of Amyotrophic Lateral Sclerosis Differ in Resting-State Functional Connectivity: An fMRI Study.

BACKGROUND

Half of all amyotrophic lateral sclerosis-frontotemporal spectrum disorder (ALS-FTSD) patients are classified as cognitively impaired, of which 10% have frontotemporal dementia (FTD), and an additional 40% suffer from a frontotemporal syndrome not severe enough to be described as dementia (cognitively impaired/ALSci). As changes in cerebral function measured by resting-state magnet resonance imaging (rs-fMRI) are known in ALS, we investigated whether group differences in resting-state functional connectivity (RSFC) networks could be observed between ALS patients with different cognitive profiles against healthy controls (HC). Furthermore, we correlated cognition and motor functioning with network connectivity.

METHODS

Healthy controls, 69, and 97 ALS patients underwent functional MRI scanning and cognitive assessment. The ALS patients were categorized as non-impaired (ALSni;

RESULTS

At a liberal alpha level of uncorrected

CONCLUSION

Resting-state functional connectivity differs between cognitive profiles of ALS and is directly associated with clinical presentation, specifically with motor function, and cognitive shifting.

Informations de copyright

Copyright © 2021 Temp, Dyrba, Büttner, Kasper, Machts, Kaufmann, Vielhaber, Teipel and Prudlo.

Déclaration de conflit d'intérêts

ST participated in scientific advisory boards of Roche Pharma AG, Biogen, Grifols SA, Dr Willmar Schwabe GmbH & Co. KG, and MSD, and received lecture fees from Roche Pharma AG and MSD. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.