Incubation of Oxycodone Craving Following Adult-Onset and Adolescent-Onset Oxycodone Self-Administration in Male Rats.
adolescent
adult rats
craving
housing
oxycodone
self-administration
Journal
Frontiers in behavioral neuroscience
ISSN: 1662-5153
Titre abrégé: Front Behav Neurosci
Pays: Switzerland
ID NLM: 101477952
Informations de publication
Date de publication:
2021
2021
Historique:
received:
19
04
2021
accepted:
25
05
2021
entrez:
12
7
2021
pubmed:
13
7
2021
medline:
13
7
2021
Statut:
epublish
Résumé
Relapse is a major obstacle to curb the ongoing epidemic of prescription opioid abuse. We and others previously demonstrated that oxycodone seeking in adult rats progressively increases after abstinence from oxycodone self-administration (incubation of oxycodone craving). In humans, the onset of oxycodone use in adolescents may increase individuals' vulnerability to later opioid addiction. However, little is known about incubation of oxycodone craving after adolescent-onset oxycodone self-administration in rats. In the first study, we trained single-housed adolescent (postnatal day 35 at start) and adult (postnatal day 77 at start) male Sprague-Dawley rats to self-administer oxycodone (0.1 mg/kg/infusion, 6 h/day for 10 days) and then tested oxycodone relapse on both abstinence day 1 and day 15. Given that social experience is critical for neurobehavioral development in adolescents, we performed the second study using group-housed adolescent and adult rats. In both studies, we observed no age differences in oxycodone self-administration and incubated oxycodone seeking on abstinence day 15. However, on abstinence day 1, we observed decreased oxycodone seeking in adolescents compared with adults. This pattern of data led to elevated incubation slopes in adolescent rats compared with adult rats. Finally, group-housed rats exhibited attenuated oxycodone seeking compared with single-housed rats on abstinence day 15, but not on day 1. Taken together, these data suggest that adolescents may be resistant to oxycodone relapse during early abstinence, but this resistance dissipates quickly during the transition between adolescent and young adulthood. In addition, group-housing plays a protective role against incubated oxycodone craving.
Identifiants
pubmed: 34248518
doi: 10.3389/fnbeh.2021.697509
pmc: PMC8262493
doi:
Types de publication
Journal Article
Langues
eng
Pagination
697509Informations de copyright
Copyright © 2021 Altshuler, Garcia and Li.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
Dev Cogn Neurosci. 2015 Dec;16:183-190
pubmed: 25575668
Sci Rep. 2021 Jan 28;11(1):2422
pubmed: 33510269
Dev Psychobiol. 1981 Jul;14(4):327-32
pubmed: 7250521
Neuroscience. 2010 Dec 29;171(4):1187-96
pubmed: 20933585
Eur J Neurosci. 2009 Mar;29(5):997-1014
pubmed: 19291226
Behav Neurosci. 2012 Oct;126(5):735-41
pubmed: 22889309
Behav Pharmacol. 2005 May;16(3):131-8
pubmed: 15864067
Psychopharmacology (Berl). 2020 Sep;237(9):2823-2833
pubmed: 32601989
Behav Neurosci. 2018 Apr;132(2):75-87
pubmed: 29481101
Psychopharmacologia. 1975;41(1):15-8
pubmed: 1168353
J Psychopharmacol. 2019 Mar;33(3):372-382
pubmed: 30644313
Physiol Behav. 2005 Jan 31;84(1):73-9
pubmed: 15642609
Nat Rev Neurosci. 2016 Jun;17(6):351-65
pubmed: 27150400
Psychopharmacology (Berl). 2012 Feb;219(3):763-73
pubmed: 21773722
JAMA. 2017 Oct 24;318(16):1539-1540
pubmed: 28832871
Psychopharmacology (Berl). 2016 Dec;233(23-24):3991-4002
pubmed: 27624598
Dev Psychobiol. 2021 Jan;63(1):125-137
pubmed: 32666555
Neurosci Biobehav Rev. 2000 Jun;24(4):417-63
pubmed: 10817843
Neurosci Biobehav Rev. 2016 Nov;70:86-105
pubmed: 27587003
Biol Psychiatry. 2018 Aug 1;84(3):213-222
pubmed: 29397902
Physiol Behav. 2019 May 1;203:10-17
pubmed: 29055749
Physiol Behav. 2003 Nov;80(2-3):317-25
pubmed: 14637231
Pharmacol Biochem Behav. 2017 Jul;158:49-56
pubmed: 28601602
Trends Neurosci. 2011 Aug;34(8):411-20
pubmed: 21764143
Drug Alcohol Depend. 1998 Jan 1;49(2):115-21
pubmed: 9543648
Front Behav Neurosci. 2020 Jan 14;13:291
pubmed: 31992975
Pharmacol Biochem Behav. 2013 Sep;110:112-6
pubmed: 23827650
MMWR Morb Mortal Wkly Rep. 2019 May 03;68(17):388-395
pubmed: 31048676
Biol Psychiatry. 2010 Jan 1;67(1):28-35
pubmed: 19709647
Psychopharmacology (Berl). 2012 Nov;224(1):91-100
pubmed: 22903388
Pharmacol Biochem Behav. 1989 Aug;33(4):903-7
pubmed: 2616610
Neuropharmacology. 2012 Sep;63(4):635-41
pubmed: 22634364
Drug Alcohol Depend. 1995 Nov;40(1):9-15
pubmed: 8746919
Nature. 2001 Jul 12;412(6843):141-2
pubmed: 11449260
Neuropharmacology. 2016 Dec;111:314-322
pubmed: 27614221
Int J Neuropsychopharmacol. 2009 Oct;12(9):1151-6
pubmed: 19691875
Pharmacol Biochem Behav. 2020 Nov;198:173022
pubmed: 32871141
Behav Neurosci. 2013 Feb;127(1):23-32
pubmed: 23398439
Behav Pharmacol. 2012 Oct;23(7):650-7
pubmed: 22914073
Neuropharmacology. 2004;47 Suppl 1:214-26
pubmed: 15464139
Neuropsychopharmacology. 2020 Apr;45(5):770-779
pubmed: 31905372
Neuropharmacology. 2018 Sep 1;139:26-40
pubmed: 29964093
Eur J Neurosci. 2010 Feb;31(4):733-41
pubmed: 20384816
Pediatrics. 2015 Nov;136(5):e1169-77
pubmed: 26504126
Biol Psychiatry. 2004 Jun 1;55(11):1082-9
pubmed: 15158427
Psychopharmacology (Berl). 2017 Dec;234(23-24):3499-3506
pubmed: 28916995
Pharmacol Biochem Behav. 2011 Apr;98(2):250-60
pubmed: 21238477
Addict Biol. 2021 Mar;26(2):e12927
pubmed: 32570285
Prog Neuropsychopharmacol Biol Psychiatry. 1997 Aug;21(6):997-1018
pubmed: 9380794
Psychopharmacology (Berl). 2010 Feb;208(2):211-22
pubmed: 19953228
Dev Psychobiol. 2004 Nov;45(3):153-62
pubmed: 15505797
Addict Biol. 2016 May;21(3):634-45
pubmed: 26202521
Psychopharmacology (Berl). 2001 May;155(3):278-84
pubmed: 11432690
Neurobiol Learn Mem. 2017 Sep;143:88-93
pubmed: 27614140
Pharmacol Biochem Behav. 2020 Mar;190:172874
pubmed: 32084492
J Neurosci. 2017 Jan 25;37(4):1014-1027
pubmed: 28123032
Addict Behav. 2009 Mar;34(3):319-22
pubmed: 19022584
Neurosci Biobehav Rev. 2017 May;76(Pt B):280-300
pubmed: 28111268
Addict Biol. 2012 Mar;17(2):365-77
pubmed: 21812872
Behav Brain Res. 2014 Aug 15;270:151-8
pubmed: 24821405
Eur Neuropsychopharmacol. 2004 Oct;14(5):355-60
pubmed: 15336295
Pharmacol Biochem Behav. 2009 Mar;92(1):164-72
pubmed: 19091300
Neuropsychopharmacology. 2013 Feb;38(3):446-54
pubmed: 23072838
Pharmacol Biochem Behav. 2020 Dec;199:173058
pubmed: 33250444
Behav Neurosci. 2011 Aug;125(4):661-7
pubmed: 21534648
Pediatrics. 2019 Feb;143(2):
pubmed: 30602544
Neuropsychopharmacology. 2009 Mar;34(4):912-22
pubmed: 18784649
Psychopharmacology (Berl). 2001 Jun;156(1):98-107
pubmed: 11465640
Behav Pharmacol. 2008 Dec;19(8):777-85
pubmed: 19020412
J Neurosci. 2012 Nov 14;32(46):16223-32
pubmed: 23152606
Psychopharmacology (Berl). 2009 Jul;204(4):725-33
pubmed: 19326103